Experience

Apton Biosystems
• United States
• Biotechnology Research
• 1 - 100 Employee
• Senior Scientist, System Integration

  • Sep 2022 - Present


Genapsys

• United States
• Biotechnology Research
• 1 - 100 Employee

• Senior Scientist and Manager, System integration and sequencing development

  • Jan 2021 - Jul 2022

  𝐈𝐧𝐯𝐨𝐥𝐯𝐞𝐝 𝐢𝐧 𝐚 𝐫𝐚𝐧𝐠𝐞 𝐨𝐟 𝐚𝐜𝐭𝐢𝐯𝐢𝐭𝐢𝐞𝐬, 𝐢𝐧𝐜𝐥𝐮𝐝𝐢𝐧𝐠 𝐬𝐲𝐬𝐭𝐞𝐦 𝐢𝐧𝐭𝐞𝐠𝐫𝐚𝐭𝐢𝐨𝐧, 𝐚𝐮𝐭𝐨𝐦𝐚𝐭𝐢𝐨𝐧, 𝐨𝐩𝐭𝐢𝐦𝐢𝐳𝐚𝐭𝐢𝐨𝐧, 𝐚𝐧𝐝 𝐯𝐞𝐫𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐆𝐞𝐧𝐚𝐩𝐒𝐲𝐬 𝐬𝐞𝐪𝐮𝐞𝐧𝐜𝐞𝐫, 𝐝𝐞𝐟𝐢𝐧𝐢𝐧𝐠 𝐩𝐞𝐫𝐟𝐨𝐫𝐦𝐚𝐧𝐜𝐞 𝐦𝐞𝐭𝐫𝐢𝐜𝐬, 𝐚𝐬 𝐰𝐞𝐥𝐥 𝐚𝐬 𝐚𝐬𝐬𝐚𝐲 𝐝𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭 𝐚𝐧𝐝 𝐭𝐫𝐚𝐧𝐬𝐟𝐞𝐫 𝐟𝐫𝐨𝐦 𝐛𝐞𝐧𝐜𝐡 𝐭𝐨 𝐢𝐧𝐬𝐭𝐫𝐮𝐦𝐞𝐧𝐭: • Integration of system's components, including CMOS chip, formulated reagents and enzymes, chemistry, polymer, software release, etc • System verification, conducting baseline studies, and root cause analysis of system's variability • Automation of amplification and sequencing workflow (single-end and paired-end), optimization of individual steps in order to achieve highest SNR and sequencing quality at shortest run-time, and generation of high quality data for training machine learning (ML) algorithms • Assay development, including solid-phase DNA amplification for generating high density clusters, with uniform size and minimum polyclonality • Formulation of various sequencing buffers using DOE • Participated in drafting a range of technical requirements (TRQs) for development of the next generation of sequencers



Northeastern University

• United States
• Higher Education
• 700 & Above Employee

• Research Scientist, Physics Department

  • Oct 2016 - Nov 2020

  𝐋𝐞𝐝 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐞𝐟𝐟𝐨𝐫𝐭𝐬 𝐢𝐧 𝐟𝐨𝐮𝐫 𝐩𝐫𝐨𝐣𝐞𝐜𝐭𝐬 𝐟𝐨𝐜𝐮𝐬𝐞𝐝 𝐨𝐧 𝐝𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭 𝐨𝐟 𝐍𝐆𝐒 𝐚𝐧𝐝 𝐢𝐦𝐦𝐮𝐧𝐨𝐚𝐬𝐬𝐚𝐲 𝐭𝐞𝐜𝐡𝐧𝐨𝐥𝐨𝐠𝐢𝐞𝐬, 𝐰𝐡𝐢𝐜𝐡 𝐫𝐞𝐬𝐮𝐥𝐭𝐞𝐝 𝐢𝐧 𝐟𝐢𝐥𝐢𝐧𝐠 4 𝐩𝐚𝐭𝐞𝐧𝐭𝐬 𝐚𝐧𝐝 𝐚𝐰𝐚𝐫𝐝𝐞𝐝 𝐛𝐲 𝐨𝐯𝐞𝐫 $3𝐌 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐠𝐫𝐚𝐧𝐭𝐬: • Innovating and developing electrically actuatable zero-mode waveguides (ZMWs) for rapid electrophoretic loading of DNA fragments into the ZMWs with negligible DNA length bias, for pg-level single-molecule real-time (SMRT) DNA and RNA sequencing • Developing a scaled-up method for synthesis of molybdenum disulfide (MoS2) 2D freestanding membranes which allowed fabrication of hundreds of leakage-free and very stable freestanding membrane devices for DNA sequencing, biosensing, and transport studies. The membranes were used to detected translocation of single DNA molecules through nanopores at an unprecedented bandwidth of 1 MHz. Project sponsored by Oxford Nanopore Technologies (ONT) • Developing alpha-hemolysin nanopore based biosensing assays using DNA hairpins of different stem lengths as the reporter molecules. These molecules were released from magnetic beads using restriction enzymes. A stable lipid bilayer platform was developed using grayscale lithography that allows increasing the applied voltage bias to 450 mV and therefore improving the capture rate of molecules • Employing nucleic acid nanoparticles (NANPs) and DNA origamis as a new class of reporter molecules for nanopore-based biosensing assay development and investigating unique deformation-controlled transport of NANPS through nanopore sensors which improves their capture efficiency by an order of magnitude • Lab setup and equipment, supervising graduate students and postdocs, design and review of experimental plans, experimentation and data analysis, and preparing research proposals