Amanda Ko (she/her)
Principal Scientist at Mercaptor Discoveries, Inc.- Claim this Profile
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Bio
Credentials
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Flow Cytometry
UC Davis: Biotechnology Program & Optical Biology CoreJul, 2013- Nov, 2024 -
Human Embryonic Stem Cell Culture Techniques at the Buck Institute
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cGMP training at the UC Davis Good Manufacturing Practice Facility
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Experience
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Mercaptor, Inc.
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United States
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Pharmaceutical Manufacturing
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1 - 100 Employee
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Principal Scientist
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May 2020 - Present
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Senior Scientist
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Jan 2017 - May 2020
Responsible for initiating, directing and executing research and development in support of Mercaptor’s multiple programs, directly managing the bench team of researchers. Serve as key strategic resource for the company’s translational development path, ensuring projects hit key milestones, capturing and managing the data that will drive Mercaptor’s lead advancement. Responsible for designing and coordinating animal studies, establishing partnering plans with leading research groups and contract research organizations to transition Captons® from the bench to appropriate disease models and further progressing compounds into pre-clinical safety and efficacy studies necessary to file Investigational New Drug applications.
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Horizon
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Ireland
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Biotechnology Research
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700 & Above Employee
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Associate Scientist
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Oct 2016 - Dec 2016
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Associate Scientist
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May 2006 - Oct 2016
Developed and performed methods for project advancement; analyzed and interpreted data; organized and presented relevant findings to the discovery team.Projects/experiments include: neuronal excitotoxicity rescue/mechanisms; enzyme production and characterization; cystinosis/cysteamine MOA studies; compound screening and characterization in HCC lines; post-translational proteomic studies; genetic screening; redox and metabolic studies; large-scale maintenance of multiple mammalian cell lines; crystallization of potential second generation drug candidates, etc. Support development of protein-based biopharmaceuticals. Created a library of domain-shuffled variants based on the human receptor-associated protein (RAP). Advanced positions over a 10-year period from Research Assistant, Research Associate, and Senior Research Associate to Associate Scientist.
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Graduate Extern
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Mar 2011 - Mar 2012
Created and maintained 27 different cell lines using a combination of oncogenes to transduce mesenchymal stem cells into pre-cancerous and transformed, cancer-like cells. These cell lines were used to model sarcomagenesis and cancer stem cells. Each cell line was characterized and compared to a mesenchymal stem cell control as well as two sarcoma cell lines: Rhabdomyosarcoma (RD) and Ewing’s sarcoma (ES). Select lines were then used as a platform to screen for novel tumor suppressors.
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Clinical Operations Assistant
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Jun 2009 - Aug 2010
Performed administrative duties, organized quality and regulatory documents and maintained correspondence with potential principle investigators and coordinators at multiple study sites around the United States.
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Education
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University of California, Davis - Graduate School of Management
Master of Business Administration - MBA -
California State University-Sacramento
M.A. Biological Sciences, Stem Cell Concentration -
California State University-Sacramento
B.S., Biological Sciences, Minor in Chemistry