Alexa Regina Avecilla
Doctoral Candidate and NIH NRSA F31 Predoctoral Fellow, Felipe Garcia Quiroz Lab at The Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University- Claim this Profile
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Experience
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The Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University
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United States
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Biotechnology Research
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100 - 200 Employee
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Doctoral Candidate and NIH NRSA F31 Predoctoral Fellow, Felipe Garcia Quiroz Lab
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Aug 2020 - Present
I am currently working on several projects harnessing intrinsically disordered proteins (IDPs) and their liquid-liquid phase separation (LLPS) abilities towards (1) the development of novel protein polymer-based biomaterials and (2) elucidating the underlying implications of LLPS in stratifying epithelia.
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Graduate Research Assistant, Susan N. Thomas Lab
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Aug 2018 - Aug 2020
My project focused on understanding the synergistic lymphatic and immune changes of mitogen-activated protein kinase (MAPK) inhibition and immune checkpoint blockade in the context of BRAF-mutated melanoma. I tested efficacy of small molecule MAPK inhibitors in the context of in vitro mammalian cell culture specifically wild-type B16F10 and BRAF-mutated D4M melanoma cell lines. In addition to in vitro studies. I also completed several in vivo murine tumor model experiments involving tumor… Show more My project focused on understanding the synergistic lymphatic and immune changes of mitogen-activated protein kinase (MAPK) inhibition and immune checkpoint blockade in the context of BRAF-mutated melanoma. I tested efficacy of small molecule MAPK inhibitors in the context of in vitro mammalian cell culture specifically wild-type B16F10 and BRAF-mutated D4M melanoma cell lines. In addition to in vitro studies. I also completed several in vivo murine tumor model experiments involving tumor inoculations and treatment injections with MAPK inhibitors and immune checkpoint blockade. At the completion of each in vivo experiment, I also harvested organs for further analysis via immunohistochemistry.
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UF Herbert Wertheim College of Engineering
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United States
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Higher Education
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100 - 200 Employee
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Teaching Assistant
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Aug 2017 - May 2018
I taught students to effectively use Microsoft Office programs to create and prepare a professional portfolio for applications for internships and job opportunities. I taught students to effectively use Microsoft Office programs to create and prepare a professional portfolio for applications for internships and job opportunities.
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J. Crayton Pruitt Family Department of Biomedical Engineering
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1 - 100 Employee
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Undergraduate Research Assistant, Benjamin G. Keselowsky Lab
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Aug 2017 - May 2018
I completed a senior honors thesis project characterizing the in vitro binding of galectin-3 fusion protein in skin for future applications as a localized drug delivery system for immunommodulatory protein therapeutics. I developed and optimized immunohistochemistry protocols for the lab, including sectioning of parafflin-embedded samples, tissue staining, and fluorescent microscopy imaging. My successful defense of this undergraduate thesis project enabled graduation with high honors (Magna… Show more I completed a senior honors thesis project characterizing the in vitro binding of galectin-3 fusion protein in skin for future applications as a localized drug delivery system for immunommodulatory protein therapeutics. I developed and optimized immunohistochemistry protocols for the lab, including sectioning of parafflin-embedded samples, tissue staining, and fluorescent microscopy imaging. My successful defense of this undergraduate thesis project enabled graduation with high honors (Magna Cum Laude). Show less I completed a senior honors thesis project characterizing the in vitro binding of galectin-3 fusion protein in skin for future applications as a localized drug delivery system for immunommodulatory protein therapeutics. I developed and optimized immunohistochemistry protocols for the lab, including sectioning of parafflin-embedded samples, tissue staining, and fluorescent microscopy imaging. My successful defense of this undergraduate thesis project enabled graduation with high honors (Magna… Show more I completed a senior honors thesis project characterizing the in vitro binding of galectin-3 fusion protein in skin for future applications as a localized drug delivery system for immunommodulatory protein therapeutics. I developed and optimized immunohistochemistry protocols for the lab, including sectioning of parafflin-embedded samples, tissue staining, and fluorescent microscopy imaging. My successful defense of this undergraduate thesis project enabled graduation with high honors (Magna Cum Laude). Show less
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University of Florida College of Medicine
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United States
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Higher Education
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500 - 600 Employee
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Administrative Support Research Assistant, Department of Health Outcomes & Policy
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Jun 2016 - Aug 2017
I worked on projects on the Operations Committee of the OneFlorida Research Consortium, a Patient-Centered Outcomes Research Institute (PCORI) designated research infrastructure that facilitates the management of clinical trials and implementation science studies at clinics in all 67 counties across Florida. I conducted literature reviews and created deliverables regarding ongoing projects to be distributed to various partners and participants within the consortium.
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Undergraduate Research Assistant, Department of Obstetrics & Gynecology
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Aug 2015 - Aug 2017
Under the guidance of Dr. Anthony Gregg in the Maternal-Fetal Medicine Division of the Department of Obstetrics and Gynecology, I worked on a project to characterize C-peptide levels during the pregnancy term. I helped with human sample collection and processing for maternal serum, urine, and placenta. Through the University Scholars Program for the College of Medicine, I had completed a histology-based project comparing the structural differences of H&E stained placenta samples and presented… Show more Under the guidance of Dr. Anthony Gregg in the Maternal-Fetal Medicine Division of the Department of Obstetrics and Gynecology, I worked on a project to characterize C-peptide levels during the pregnancy term. I helped with human sample collection and processing for maternal serum, urine, and placenta. Through the University Scholars Program for the College of Medicine, I had completed a histology-based project comparing the structural differences of H&E stained placenta samples and presented this work at the 2017 Undergraduate Research Symposium at the University of Florida.
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University of Illinois Urbana-Champaign
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United States
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Higher Education
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700 & Above Employee
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EBICS REU Undergraduate Research Assistant, Rashid Bashir Lab
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May 2017 - Jul 2017
I completed a brief research project towards the development of skeletal muscle powered biological machines. Here, I evaluated the viability, differentiation, and transfection efficiency of Chrimson channelrhodopsin-transfected C2C12 skeletal muscle cells. I presented this work at the Illinois Summer Research Symposium, the EBICS Annual Retreat in Callaway Gardens, GA, and the BMES Annual Meeting 2017 in Phoenix, AZ. I completed a brief research project towards the development of skeletal muscle powered biological machines. Here, I evaluated the viability, differentiation, and transfection efficiency of Chrimson channelrhodopsin-transfected C2C12 skeletal muscle cells. I presented this work at the Illinois Summer Research Symposium, the EBICS Annual Retreat in Callaway Gardens, GA, and the BMES Annual Meeting 2017 in Phoenix, AZ.
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Education
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Emory University
Doctor of Philosophy - PhD -
The Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University
Doctor of Philosophy - PhD, Biomedical/Medical Engineering -
University of Florida
Bachelor of Science - BS, Bioengineering and Biomedical Engineering -
Georgia Institute of Technology
Doctor of Philosophy - PhD