Alexa Regina Avecilla

Doctoral Candidate and NIH NRSA F31 Predoctoral Fellow, Felipe Garcia Quiroz Lab at The Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University
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Contact Information
us****@****om
(386) 825-5501
Location
Atlanta, Georgia, United States, GE

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Experience

    • Doctoral Candidate and NIH NRSA F31 Predoctoral Fellow, Felipe Garcia Quiroz Lab
      • Aug 2020 - Present

      I am currently working on several projects harnessing intrinsically disordered proteins (IDPs) and their liquid-liquid phase separation (LLPS) abilities towards (1) the development of novel protein polymer-based biomaterials and (2) elucidating the underlying implications of LLPS in stratifying epithelia.

    • Graduate Research Assistant, Susan N. Thomas Lab
      • Aug 2018 - Aug 2020

      My project focused on understanding the synergistic lymphatic and immune changes of mitogen-activated protein kinase (MAPK) inhibition and immune checkpoint blockade in the context of BRAF-mutated melanoma. I tested efficacy of small molecule MAPK inhibitors in the context of in vitro mammalian cell culture specifically wild-type B16F10 and BRAF-mutated D4M melanoma cell lines. In addition to in vitro studies. I also completed several in vivo murine tumor model experiments involving tumor… Show more My project focused on understanding the synergistic lymphatic and immune changes of mitogen-activated protein kinase (MAPK) inhibition and immune checkpoint blockade in the context of BRAF-mutated melanoma. I tested efficacy of small molecule MAPK inhibitors in the context of in vitro mammalian cell culture specifically wild-type B16F10 and BRAF-mutated D4M melanoma cell lines. In addition to in vitro studies. I also completed several in vivo murine tumor model experiments involving tumor inoculations and treatment injections with MAPK inhibitors and immune checkpoint blockade. At the completion of each in vivo experiment, I also harvested organs for further analysis via immunohistochemistry.

    • United States
    • Higher Education
    • 100 - 200 Employee
    • Teaching Assistant
      • Aug 2017 - May 2018

      I taught students to effectively use Microsoft Office programs to create and prepare a professional portfolio for applications for internships and job opportunities. I taught students to effectively use Microsoft Office programs to create and prepare a professional portfolio for applications for internships and job opportunities.

    • Undergraduate Research Assistant, Benjamin G. Keselowsky Lab
      • Aug 2017 - May 2018

      I completed a senior honors thesis project characterizing the in vitro binding of galectin-3 fusion protein in skin for future applications as a localized drug delivery system for immunommodulatory protein therapeutics. I developed and optimized immunohistochemistry protocols for the lab, including sectioning of parafflin-embedded samples, tissue staining, and fluorescent microscopy imaging. My successful defense of this undergraduate thesis project enabled graduation with high honors (Magna… Show more I completed a senior honors thesis project characterizing the in vitro binding of galectin-3 fusion protein in skin for future applications as a localized drug delivery system for immunommodulatory protein therapeutics. I developed and optimized immunohistochemistry protocols for the lab, including sectioning of parafflin-embedded samples, tissue staining, and fluorescent microscopy imaging. My successful defense of this undergraduate thesis project enabled graduation with high honors (Magna Cum Laude). Show less I completed a senior honors thesis project characterizing the in vitro binding of galectin-3 fusion protein in skin for future applications as a localized drug delivery system for immunommodulatory protein therapeutics. I developed and optimized immunohistochemistry protocols for the lab, including sectioning of parafflin-embedded samples, tissue staining, and fluorescent microscopy imaging. My successful defense of this undergraduate thesis project enabled graduation with high honors (Magna… Show more I completed a senior honors thesis project characterizing the in vitro binding of galectin-3 fusion protein in skin for future applications as a localized drug delivery system for immunommodulatory protein therapeutics. I developed and optimized immunohistochemistry protocols for the lab, including sectioning of parafflin-embedded samples, tissue staining, and fluorescent microscopy imaging. My successful defense of this undergraduate thesis project enabled graduation with high honors (Magna Cum Laude). Show less

    • United States
    • Higher Education
    • 500 - 600 Employee
    • Administrative Support Research Assistant, Department of Health Outcomes & Policy
      • Jun 2016 - Aug 2017

      I worked on projects on the Operations Committee of the OneFlorida Research Consortium, a Patient-Centered Outcomes Research Institute (PCORI) designated research infrastructure that facilitates the management of clinical trials and implementation science studies at clinics in all 67 counties across Florida. I conducted literature reviews and created deliverables regarding ongoing projects to be distributed to various partners and participants within the consortium.

    • Undergraduate Research Assistant, Department of Obstetrics & Gynecology
      • Aug 2015 - Aug 2017

      Under the guidance of Dr. Anthony Gregg in the Maternal-Fetal Medicine Division of the Department of Obstetrics and Gynecology, I worked on a project to characterize C-peptide levels during the pregnancy term. I helped with human sample collection and processing for maternal serum, urine, and placenta. Through the University Scholars Program for the College of Medicine, I had completed a histology-based project comparing the structural differences of H&E stained placenta samples and presented… Show more Under the guidance of Dr. Anthony Gregg in the Maternal-Fetal Medicine Division of the Department of Obstetrics and Gynecology, I worked on a project to characterize C-peptide levels during the pregnancy term. I helped with human sample collection and processing for maternal serum, urine, and placenta. Through the University Scholars Program for the College of Medicine, I had completed a histology-based project comparing the structural differences of H&E stained placenta samples and presented this work at the 2017 Undergraduate Research Symposium at the University of Florida.

    • United States
    • Higher Education
    • 700 & Above Employee
    • EBICS REU Undergraduate Research Assistant, Rashid Bashir Lab
      • May 2017 - Jul 2017

      I completed a brief research project towards the development of skeletal muscle powered biological machines. Here, I evaluated the viability, differentiation, and transfection efficiency of Chrimson channelrhodopsin-transfected C2C12 skeletal muscle cells. I presented this work at the Illinois Summer Research Symposium, the EBICS Annual Retreat in Callaway Gardens, GA, and the BMES Annual Meeting 2017 in Phoenix, AZ. I completed a brief research project towards the development of skeletal muscle powered biological machines. Here, I evaluated the viability, differentiation, and transfection efficiency of Chrimson channelrhodopsin-transfected C2C12 skeletal muscle cells. I presented this work at the Illinois Summer Research Symposium, the EBICS Annual Retreat in Callaway Gardens, GA, and the BMES Annual Meeting 2017 in Phoenix, AZ.

Education

  • Emory University
    Doctor of Philosophy - PhD
    2018 -
  • The Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University
    Doctor of Philosophy - PhD, Biomedical/Medical Engineering
    2018 -
  • University of Florida
    Bachelor of Science - BS, Bioengineering and Biomedical Engineering
    2014 - 2018
  • Georgia Institute of Technology
    Doctor of Philosophy - PhD
    2018 -

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