PhD Student - Department of Pharmaceutical Chemistry and Bioanalytics,Charles Tanford Protein Center

• Nov 2019 - Present

- Characterization of full length human tumor suppressor p53 by means of structural mass spectrometry-based techniques (XL-MS, Native MS, Covalent labeling, HDX-MS etc); - Development of novel trifunctional MS/MS-cleavable crosslinkers for protein structure analysis and proteome-wide crosslinking studies (CuAAC- or Phospho-enrichment of cross-linked peptides); - Teaching assistant for the Analytical Chemistry, Quantitative Drug Analysis practical courses, Department of Pharmacy. - Characterization of full length human tumor suppressor p53 by means of structural mass spectrometry-based techniques (XL-MS, Native MS, Covalent labeling, HDX-MS etc); - Development of novel trifunctional MS/MS-cleavable crosslinkers for protein structure analysis and proteome-wide crosslinking studies (CuAAC- or Phospho-enrichment of cross-linked peptides); - Teaching assistant for the Analytical Chemistry, Quantitative Drug Analysis practical courses, Department of Pharmacy.

Research Trainee - Department of Food and Drug

• Apr 2019 - Oct 2019

Enrolled as Research trainee at the Proteomics and Bioanalytical Chemistry lab of prof. Lisa Elviri. • Protein extraction from biological samples by means of different extraction protocols; • Analysis of protein content through Bradford assay; • Analysis of data derived from proteomic experiments by means of MaxQuant and Perseus software packages; • Preparation of alginate and chitosane-based 3D scaffolds for their use in regenerative medicine. Enrolled as Research trainee at the Proteomics and Bioanalytical Chemistry lab of prof. Lisa Elviri. • Protein extraction from biological samples by means of different extraction protocols; • Analysis of protein content through Bradford assay; • Analysis of data derived from proteomic experiments by means of MaxQuant and Perseus software packages; • Preparation of alginate and chitosane-based 3D scaffolds for their use in regenerative medicine.

Pharmacist

• Apr 2019 - Oct 2019

Trainee - Preclinical Chemistry Research & Drug Design Department, Chiesi Farmaceutici

• Jun 2018 - Dec 2018

• Support to the identification and evaluation of novel computational methodologies applied to the discovery projects; • Application of molecular modeling and chemometric techniques for the identification of potential lead compounds; • Prediction and evaluation of phys-chem properties of compounds(pka, LogP, LogD, Solubility, etc.); • Deepening of multivariate analysis techniques for the statistical treatment of scientific data (PCA, PLS) and biophysics techniques used in Drug Discovery (NMR, Mass Spectrometry, X-ray crystallography, Cryo-EM etc); • Development of new molecular modeling techniques for the prediction of the binding mode conformation of small organic molecules to their target if the three-dimensional structure of the complex isn’t already known; • Participation to multidisciplinary seminar activities related to the discovery projects; Show less

Master Degree Research Thesis Project

• Jan 2017 - Sep 2017

Experimental Thesis Research Project: “Protein-Protein Interaction Studies through Enhanced Sampling Techniques” in the Drug Design & Discovery lab of prof. Marco Mor, University of Parma: • Application of molecular modeling techniques for the identification of the binding mode conformation of the lipophilic chemotactic peptide BOC2 to VEGFp165-HBD; • Design of new peptidic ligands endowed with antiangiogenic activity used as pharmacological tools in Proliferative Diabetic Retinopathy (PDR) and angiogenesis-dependent tumors; Show less

Internship Student

• Apr 2016 - Oct 2016

• Organization of the pharmaceutical storehouse; • Selling of medicines subjected to medical prescription, OTC and SOP, supplements, ecc; • Blood pressure, cholesterol ed ECG measurement; • Preparation of creams, ointments, solutions, lotions in galenic lab; • Order, sending and closure of DPC products. • Organization of the pharmaceutical storehouse; • Selling of medicines subjected to medical prescription, OTC and SOP, supplements, ecc; • Blood pressure, cholesterol ed ECG measurement; • Preparation of creams, ointments, solutions, lotions in galenic lab; • Order, sending and closure of DPC products.