Ai Lin Chin
Scientist I, In Vivo Lead at Federation Bio- Claim this Profile
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English Native or bilingual proficiency
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Chinese Native or bilingual proficiency
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Malay Professional working proficiency
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Experience
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Federation Bio
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United States
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Biotechnology Research
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1 - 100 Employee
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Scientist I, In Vivo Lead
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Feb 2023 - Present
Development of microbiome therapy towards treatment of inflammatory bowel diseases • Advancing a microbial consortium designed to remodel gut microflora for remission and maintenance of ulcerative colitis with minimal flare-ups. • Leading in vivo efforts in forming relevant hypothesis and designing animal studies to build a desired data package for IND application purposes. • Coordinating sub-projects with external vendors to fulfill additional portfolio needs. • Regularly… Show more Development of microbiome therapy towards treatment of inflammatory bowel diseases • Advancing a microbial consortium designed to remodel gut microflora for remission and maintenance of ulcerative colitis with minimal flare-ups. • Leading in vivo efforts in forming relevant hypothesis and designing animal studies to build a desired data package for IND application purposes. • Coordinating sub-projects with external vendors to fulfill additional portfolio needs. • Regularly presenting internal research team with research progress updates and new experimental designs. • Consistently self-improving through relevant scientific literature.
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Senior Research Associate
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Feb 2022 - Jan 2023
Anti-tumor vaccine delivery using skin commensal derived bacterial vector • Developing targeted delivery of tumor antigens through engineered S. epidermidis to eliminate skin cancer. • Leading strategies in documenting and mitigating S. epi associated inflammation driven skin lesions. • Enhancing T cell responses in pharmacodynamics studies using transgenic mouse models. • Performing immune cell phenotype analysis using multicolor flow cytometry. • Designing and presenting safety… Show more Anti-tumor vaccine delivery using skin commensal derived bacterial vector • Developing targeted delivery of tumor antigens through engineered S. epidermidis to eliminate skin cancer. • Leading strategies in documenting and mitigating S. epi associated inflammation driven skin lesions. • Enhancing T cell responses in pharmacodynamics studies using transgenic mouse models. • Performing immune cell phenotype analysis using multicolor flow cytometry. • Designing and presenting safety and toxicity studies in cross-functional team meetings. • Assisting in writing of experimental SOP to ensure uniformity across research groups.
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Virginia Tech
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United States
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Higher Education
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700 & Above Employee
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Graduate Research And Teaching Assistant
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Aug 2016 - Dec 2021
Graduate Research Assistant • Designed an implantable biomedical device for treatment of aggressive cancer and electrochemical impedance tracking of treatment response • Developed immunotherapeutic treatment regimen towards metastatic tumors by syngenic combination of photodynamic and checkpoint blockade therapies • Performing in vitro plate-based assays, drug efficacy studies in ex vivo biological specimens, in vivo transplantable tumors in transgenic and wild-type mouse models •… Show more Graduate Research Assistant • Designed an implantable biomedical device for treatment of aggressive cancer and electrochemical impedance tracking of treatment response • Developed immunotherapeutic treatment regimen towards metastatic tumors by syngenic combination of photodynamic and checkpoint blockade therapies • Performing in vitro plate-based assays, drug efficacy studies in ex vivo biological specimens, in vivo transplantable tumors in transgenic and wild-type mouse models • Proficient in aseptic tumor cell culture, xenograft tumor inoculation, laboratory mice handling • Conducted tumor microenvironment studies of immune cell phenotypes in response to immunotherapy using multicolor flow cytometry, intracellular cytokine stimulation and detection, and immunohistochemistry staining • Collection and analysis of experimental data using IVIS Spectrum, LI-COR Odyssey, FlowJo, ImageJ, OriginPro, and Gamry Instruments softwares Graduate Teaching Assistant • Assisted with multiple sessions of undergraduate thermodynamics and separation processes • Responsibilities included providing solutions to assignment and exam questions, grading of submitted assignments and exams, tutored students on questions relating to materials taught in class Show less Graduate Research Assistant • Designed an implantable biomedical device for treatment of aggressive cancer and electrochemical impedance tracking of treatment response • Developed immunotherapeutic treatment regimen towards metastatic tumors by syngenic combination of photodynamic and checkpoint blockade therapies • Performing in vitro plate-based assays, drug efficacy studies in ex vivo biological specimens, in vivo transplantable tumors in transgenic and wild-type mouse models •… Show more Graduate Research Assistant • Designed an implantable biomedical device for treatment of aggressive cancer and electrochemical impedance tracking of treatment response • Developed immunotherapeutic treatment regimen towards metastatic tumors by syngenic combination of photodynamic and checkpoint blockade therapies • Performing in vitro plate-based assays, drug efficacy studies in ex vivo biological specimens, in vivo transplantable tumors in transgenic and wild-type mouse models • Proficient in aseptic tumor cell culture, xenograft tumor inoculation, laboratory mice handling • Conducted tumor microenvironment studies of immune cell phenotypes in response to immunotherapy using multicolor flow cytometry, intracellular cytokine stimulation and detection, and immunohistochemistry staining • Collection and analysis of experimental data using IVIS Spectrum, LI-COR Odyssey, FlowJo, ImageJ, OriginPro, and Gamry Instruments softwares Graduate Teaching Assistant • Assisted with multiple sessions of undergraduate thermodynamics and separation processes • Responsibilities included providing solutions to assignment and exam questions, grading of submitted assignments and exams, tutored students on questions relating to materials taught in class Show less
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Tennessee Technological University
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United States
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Higher Education
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700 & Above Employee
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Research Assistant
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Aug 2015 - May 2016
• Developed modular synthesis of diversified soft lewis basic complexants • Modification of cross-coupling catalytic pathways to afford dialkylation of heteroaryl molecules • Trained 2 junior lab members on using NMR / FTIR spectroscopy and performing flash column and thin layer chromatography purifications of organic compounds • Developed modular synthesis of diversified soft lewis basic complexants • Modification of cross-coupling catalytic pathways to afford dialkylation of heteroaryl molecules • Trained 2 junior lab members on using NMR / FTIR spectroscopy and performing flash column and thin layer chromatography purifications of organic compounds
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Education
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Virginia Tech
Doctor of Philosophy - PhD, Chemical Engineering, Drug Delivery, Cancer -
Virginia Tech
Master of Engineering - MEng, Chemical Engineering -
Tennessee Technological University
Bachelor of Science - BS, Chemical Engineering