Abe Tolley

Neurobiology Supervisor at Christ's College Cambridge
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Contact Information
us****@****om
(386) 825-5501
Location
Cambridge, England, United Kingdom, GB

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Experience

    • United Kingdom
    • Higher Education
    • 1 - 100 Employee
    • Neurobiology Supervisor
      • Sep 2021 - Present

      Medical Sciences Tripos - Part IB - NHB (Neurobiology and Human Behaviour) Supervising second year undergraduate medical students at Christ's College Cambridge in Neurobiology. Medical Sciences Tripos - Part IB - NHB (Neurobiology and Human Behaviour) Supervising second year undergraduate medical students at Christ's College Cambridge in Neurobiology.

    • United Kingdom
    • Fundraising
    • 1 - 100 Employee
    • Operations Lead & Founding Team
      • Nov 2018 - Present

      Raise (www.joinraise.org) is a UK wide student charity movement which encourages students to adopt a positive, deliberate approach to effective giving. Since its founding in Cambridge in 2018 with the name 'MWA - May Week Alternative', the movement has raised over £280,000 with the support of over 1,000 students, enough to protect over 300,000 people from malaria. There are currently chapters in Cambridge, Durham, Glasgow and Oxford, with operations coordinated nationally and there are plans to continue to expand to further universities. Previous Roles: MWA President (2020-21), Vice President (2019-2020), Rep Coordinator (2018-2019)In 2020-21, despite the Covid-19 pandemic, MWA raised over £70,000 with more than 400 students joining. A committee of 16 students and over 70 reps around the university co-ordinated publicity, ran the annual fundraising period and organised a virtual national launch event with chapters at 3 other universities. They also organised the annual Summer Party within Covid-19 guidelines where all those who joined MWA come together to celebrate their collective impact.

    • United Kingdom
    • Non-profit Organizations
    • 1 - 100 Employee
    • Fellow
      • Jul 2021 - Sep 2021

      8 Week fellowship with EA Cambridge exploring current global challenges and how to develop the best solutions. The programme includes studying aspects of economics, philosophy, statistics, psychology, social activism, charitable giving and artificial intelligence. 8 Week fellowship with EA Cambridge exploring current global challenges and how to develop the best solutions. The programme includes studying aspects of economics, philosophy, statistics, psychology, social activism, charitable giving and artificial intelligence.

    • United Kingdom
    • Research Services
    • 700 & Above Employee
    • Research Internship
      • Jul 2021 - Aug 2021

      Summer research intern with the Protasio Group in Department of Pathology. Researching transposable elements in parasitic flatworms. Awarded Pathological Society Undergraduate Elective Bursary. Summer research intern with the Protasio Group in Department of Pathology. Researching transposable elements in parasitic flatworms. Awarded Pathological Society Undergraduate Elective Bursary.

    • President
      • Sep 2020 - Jul 2021

      Christ's College Medical Society provides for over 60 students studying Medicine at Christ's, running educational and social events, and facilitating collaborations between undergraduate and clinical students. Christ's College Medical Society provides for over 60 students studying Medicine at Christ's, running educational and social events, and facilitating collaborations between undergraduate and clinical students.

    • United Kingdom
    • Research Services
    • 700 & Above Employee
    • Research Project
      • Oct 2020 - Mar 2021

      Undertook 6 month research project entitled “Expression of endoretroviruses in human cancer cell lines” with Protasio & Smith Groups in the Department of Pathology as part of the third year of my degree. Used Unix/ Linux, R and computer cluster systems for large dataset processing and analysis. Awarded Department of Pathology's Dr A. Max Barrett Prize in Cellular Pathology for the best Cancer & Genetic Disease project. Abstract Human endogenous retroviruses (HERVs) are a class of transposable elements and make up around 8% of the human genome. They are dysregulated in human diseases including cancer, although their function is poorly understood and they may play causative or passenger roles in a context dependent fashion. HERVs are also putative cancer biomarkers whose expression could be used to inform prognosis and clinical decision making. To improve understanding of their role in cancer aetiology, the differential expression of HERVs between two gastrointestinal cancers was analysed as a model system in this study. Locus-specific HERV expression was quantified using RNA-sequence data from oesophageal squamous cell carcinoma- and colon adenocarcinoma- derived cancer cell lines. 99 differentially expressed HERVs were identified and their locations assessed. In parallel, HERV differential expression between squamous cell carcinomas and adenocarcinomas was analysed and no significantly differentially expressed loci found. In these cancer cell lines, it was also found that HERV expression in adenocarcinomas was more heterogenous than in squamous cell carcinomas. Findings indicate a greater association of HERVs with the histological subtypes of gastrointestinal than lung cancer cell lines, highlighting these as good options for future work in assessing HERV functionality and characterising HERVs as possible cancer biomarkers.

    • Content Lead
      • May 2020 - Jul 2020

      With May Balls cancelled due to the Covid-19 pandemic, the May Week Mega Event brought together the Cambridge community for a virtual extravaganza to celebrate the end of a tough term and raise money for charity.The Mega Event was a cross-Cambridge collaboration between MWA, RAG and the May Ball Presidents' Committee and took the form of a 5-hour livestream. The event featured contributions from more than 500 students, staff and alumni, including celebrities such as Clare Balding, Andy Parsons and Dame Emma Thompson, and attracted more than 10,000 viewers, raising over £14,000 for charity.

    • United Kingdom
    • Research Services
    • 700 & Above Employee
    • Student Intern
      • Sep 2019 - Sep 2019

      Internship with Dr Hilary Martin who runs a group focussed on medical and population genetics at the Sanger Institute. Carried out classification and analysis of Loss of Function variants from genome sequence data. Analysed genetic sequence data using R as well as presenting a paper on pext scores at weekly journal club. Internship with Dr Hilary Martin who runs a group focussed on medical and population genetics at the Sanger Institute. Carried out classification and analysis of Loss of Function variants from genome sequence data. Analysed genetic sequence data using R as well as presenting a paper on pext scores at weekly journal club.

    • United Kingdom
    • Team Lead
      • 2017 - 2018

      iGEM, international genetically engineered machine, is a worldwide competition, where students use synthetic biology to help solve global problems. The City of London School iGEM team - designed a genetic circuit to diagnose cancer at an early stage by using micro-RNAs. Presented our findings at finals in Boston, USA and were awarded- Gold Medal - Best Integrated Human Practices, Best New Composite Part, Best Hardware, Best SoftwareDeveloped & tested the genetic circuit in the lab, discussed the clinical implementation of our project with doctors, modelled the cost efficacy of our tool and presented our project to students, staff and alumni. More details at our wiki: http://2017.igem.org/Team:CLSB-UK

Education

  • University of Cambridge
    Bachelor of Medicine, Bachelor of Surgery (MBBS), Clinical Medicine
    2021 - 2024
  • University of Cambridge
    Bachelor of Arts (B.A.), Preclinical Medicine, Pathology
    2018 - 2021
  • City of London School
    2010 - 2018

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