Scientist II

• Feb 2023 - Present

Scientist I

• Jan 2022 - Jan 2023

Research Assistant

• Sep 2015 - Jan 2022

I work on membrane proteins involved in the transmission of auditory information through synapses. The lab uses zebrafish as a model organism in trying to decipher the mechanism by which these proteins cause the release of neurotransmitters that aid the process of hearing. My project is the characterization of different chunks of the Otoferlin protein and compare it to the full-length protein. In addition to using zebrafish, I use mammalian cell lines and bacteria to study proteins. I also… Show more I work on membrane proteins involved in the transmission of auditory information through synapses. The lab uses zebrafish as a model organism in trying to decipher the mechanism by which these proteins cause the release of neurotransmitters that aid the process of hearing. My project is the characterization of different chunks of the Otoferlin protein and compare it to the full-length protein. In addition to using zebrafish, I use mammalian cell lines and bacteria to study proteins. I also employ various molecular and biochemical assays to characterize Otoferlin and it's partner proteins. This project has resulted in various peer-reviewed publications and media articles mentioned below. https://www.sciencedaily.com/releases/2021/05/210519080438.htm https://www.clinicalomics.com/topics/precision-medicine-topic/gene-therapy/osu-researchers-make-advances-in-developing-gene-therapy-to-allow-the-deaf-to-hear/ https://www.hearingreview.com/tag/aayushi-manchanda https://www.eurekalert.org/news-releases/886732 https://newsline.news/due-to-new-discoveries-gene-therapy-can-restore-the-hearing-of-deaf-mute-people-after-birth/ https://www.audiology-worldnews.com/research/3638-congenitally-deaf-have-rewired-brains-that-need-different-teaching-approaches Show less I work on membrane proteins involved in the transmission of auditory information through synapses. The lab uses zebrafish as a model organism in trying to decipher the mechanism by which these proteins cause the release of neurotransmitters that aid the process of hearing. My project is the characterization of different chunks of the Otoferlin protein and compare it to the full-length protein. In addition to using zebrafish, I use mammalian cell lines and bacteria to study proteins. I also… Show more I work on membrane proteins involved in the transmission of auditory information through synapses. The lab uses zebrafish as a model organism in trying to decipher the mechanism by which these proteins cause the release of neurotransmitters that aid the process of hearing. My project is the characterization of different chunks of the Otoferlin protein and compare it to the full-length protein. In addition to using zebrafish, I use mammalian cell lines and bacteria to study proteins. I also employ various molecular and biochemical assays to characterize Otoferlin and it's partner proteins. This project has resulted in various peer-reviewed publications and media articles mentioned below. https://www.sciencedaily.com/releases/2021/05/210519080438.htm https://www.clinicalomics.com/topics/precision-medicine-topic/gene-therapy/osu-researchers-make-advances-in-developing-gene-therapy-to-allow-the-deaf-to-hear/ https://www.hearingreview.com/tag/aayushi-manchanda https://www.eurekalert.org/news-releases/886732 https://newsline.news/due-to-new-discoveries-gene-therapy-can-restore-the-hearing-of-deaf-mute-people-after-birth/ https://www.audiology-worldnews.com/research/3638-congenitally-deaf-have-rewired-brains-that-need-different-teaching-approaches Show less

Project Assistant

• Apr 2015 - Jul 2015

Worked in the Virology Department of King George’s Medical College where my duty was diagnosing respiratory viruses in patient samples, and scientific writing. I worked mainly with Influenza viruses and other respiratory viruses like- Bocavirus, Rhinovirus, Adenovirus, Respiratory Syncital Virus, etc. Worked in the Virology Department of King George’s Medical College where my duty was diagnosing respiratory viruses in patient samples, and scientific writing. I worked mainly with Influenza viruses and other respiratory viruses like- Bocavirus, Rhinovirus, Adenovirus, Respiratory Syncital Virus, etc.

Project Assistant

• Nov 2014 - Apr 2015

My work involved characterization of various genes involved in metabolic pathways in plants by using protein expression and other molecular based methods. My work involved characterization of various genes involved in metabolic pathways in plants by using protein expression and other molecular based methods.