Aarti Rohira

at Empress Therapeutics
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Contact Information
us****@****om
(386) 825-5501
Location
Cambridge, Massachusetts, United States, US

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Experience

    • United States
    • Biotechnology Research
    • 1 - 100 Employee
      • Mar 2023 - Present

      • Nov 2021 - Feb 2023

    • United States
    • Higher Education
    • 700 & Above Employee
      • Aug 2020 - Nov 2021

      Mentor: Dr. Bert W. O’MalleyPre-clinical drug development and testing in disease models of cancer, kidney fibrosis and cardiovascular diseaseo Established cancer stem cell models utilizing 2D/3D culture systems to test the efficacy of steroid receptor coactivator inhibitors in blocking cancer stem cell growth o Identified epithelial to mesenchymal transition (EMT) as the regulatory mechanism of the steroid receptor coactivators on cancer stem cell growth and survivalo Discovered the cardio protective effect of steroid receptor coactivator stimulators after myocardial infarctiono Discovered protective role for SRC stimulator for kidney fibrosis after kidney injuryo Utilized Magnetic Activated Cell Sorting (MACS) technology to isolate and separate immune cells from bone marrow to identify and validate immune mediated effects of drug on kidney and heart after injuryo Utilized in vitro differentiation assays to examine drug regulated cellular plasticityo Examined effect of SRC stimulators on fibrosis in fibroblastso Managed collaborations across multiple departments and mentored undergraduate students and technicians Show less

      • Jan 2014 - Aug 2020

      Mentor: Dr. Bert W. O’Malley

    • United States
    • Higher Education
    • 700 & Above Employee
      • Jun 2013 - Dec 2013

      Mentor: Dr. Deborah JohnsonTranscriptional regulation of metabolism in hepatocellular carcinomao Identified Maf1 as a negative regulator of de novo lipogenesis through transcriptional repression of lipogenic enzymes FASN and ACC1o Described a novel tumor suppressor function for Maf1 in HCC

      • Aug 2007 - May 2013

      Mentor: Dr. Deborah Johnsono Identified sumoylation as a novel pathway that regulates RNA polymerase III dependent gene transcription o Used structure-function and site-directed mutagenesis to characterize the regulatory action of Maf1

      • Aug 2010 - Jul 2012

  • Genetics Diagnostic Center
    • Mumbai Area, India
    • Summer Intern
      • Apr 2004 - May 2004

      • Leucocyte culture technique • Planting and Harvesting blood samples • G-Banding technique • Analysis of chromosomes & preparation of karyotype • Leucocyte culture technique • Planting and Harvesting blood samples • G-Banding technique • Analysis of chromosomes & preparation of karyotype

    • India
    • Biotechnology Research
    • 700 & Above Employee
    • Summer Intern
      • Apr 2003 - Jun 2003

      • Setting up of HIV, HBV, CMV, DNA PCR’s and HIV, HCV RT-PCR’s for clinical diagnosis • Human genomic DNA extraction and HLA low resolution SSP and SSOP PCR’s • Preparation of plasmid constructs which involved molecular techniques like cloning and amplification for the Human Parvovirus B-19 strain • Setting up of HIV, HBV, CMV, DNA PCR’s and HIV, HCV RT-PCR’s for clinical diagnosis • Human genomic DNA extraction and HLA low resolution SSP and SSOP PCR’s • Preparation of plasmid constructs which involved molecular techniques like cloning and amplification for the Human Parvovirus B-19 strain

Education

  • University of Southern California
    Doctor of Philosophy (Ph.D.), Genetics, Molecular and Cellular Biology
    2007 - 2013
  • University of Mumbai
    Bachelor's of Science (B.Sc.), Biotechnology
    2002 - 2005

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