Aaron Tipton, PhD
Process Development Scientist at Cytovance Biologics- Claim this Profile
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Bio
Experience
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Cytovance Biologics
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United States
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Biotechnology Research
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100 - 200 Employee
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Process Development Scientist
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Mar 2021 - Present
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Oklahoma Medical Research Foundation
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United States
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Research Services
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300 - 400 Employee
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Jul 2019 - Mar 2021
Examined microtubule dynamics within the mitotic spindle through the use of confocal microscopy, live cell imaging, and photoactivation assays followed by curve fitting utilizing PRISM to determine microtubule population turnover and half-life. This work uncovered the presence of more than just 2 microtubule populations within the mitotic spindle.
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Aug 2012 - Jul 2019
Identification and characterization of the mechanisms, pathways, and function of the protein G2 and S-phase Expressed 1 (GTSE1) during mitosis through the use of immunofluorescence techniques, confocal microscopy, live cell imaging, photoactivation assays, protein purification in bacteria, column chromatography, biochemical assays, western blot analysis, and molecular cloning. This work uncovered the role of GTSE1 in mediating chromosome alignment during mitosis. Additionally, identified GTSE1 as a potential chemotherapeutic target. Show less
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ASCB-KGI Biotechnology Training Course
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Claremont, California
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Student
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Jul 2019 - Jul 2019
Focus: Gain an understanding of how science is conducted and commercialized in industry. Understand core business competencies necessary for the transition from academia to industry. Focus: Gain an understanding of how science is conducted and commercialized in industry. Understand core business competencies necessary for the transition from academia to industry.
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Marine Biological Laboratory
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United States
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Research Services
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200 - 300 Employee
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Student (Physiology Course)
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Jun 2014 - Aug 2014
7 week intensive research training course focused on molecular, biological, computational, and physical sciences 7 week intensive research training course focused on molecular, biological, computational, and physical sciences
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The University of Toledo
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Higher Education
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700 & Above Employee
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Doctoral Candidate
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Aug 2007 - Jun 2012
Examined the mechanisms regulating mitotic checkpoint assembly and function through the use of protein purification in bacteria, insect, and mammalian cells, column chromatography, AKTA FPLC system, in vitro biochemical assays, binding kinetics assays, western blot analysis, and molecular cloning. This work first identified a direct interaction between MCC components BUBR1 and MAD2, and defined mechanisms resulting in MCC mediated APC/C inhibition. Examined the mechanisms regulating mitotic checkpoint assembly and function through the use of protein purification in bacteria, insect, and mammalian cells, column chromatography, AKTA FPLC system, in vitro biochemical assays, binding kinetics assays, western blot analysis, and molecular cloning. This work first identified a direct interaction between MCC components BUBR1 and MAD2, and defined mechanisms resulting in MCC mediated APC/C inhibition.
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The University of Toledo
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Higher Education
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700 & Above Employee
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2006 - 2007
Examined the role of human Guanylate-Binding Protein-1 (hGBP-1) in paclitaxel resistance through the use of cell based assays following drug treatment and immunofluorescence.
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2005 - 2006
Characterization of the intracellular localization of murine Guanylate-Binding Protein (mGBP) family members through transient expression in cells and immunofluorescence.
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Education
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The University of Toledo
Doctor of Philosophy - PhD, Cellular and Molecular Biology -
The University of Toledo
Biology/Biological Sciences, General -
Owens Community College
Biology/Biological Sciences, General -
Walsh University
Bachelor of Arts - BA, Marketing