Aaron Tipton, PhD

Process Development Scientist at Cytovance Biologics
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Contact Information
us****@****om
(386) 825-5501
Location
Oklahoma City, Oklahoma, United States, US

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Experience

    • United States
    • Biotechnology Research
    • 100 - 200 Employee
    • Process Development Scientist
      • Mar 2021 - Present

    • United States
    • Research Services
    • 300 - 400 Employee
      • Jul 2019 - Mar 2021

      Examined microtubule dynamics within the mitotic spindle through the use of confocal microscopy, live cell imaging, and photoactivation assays followed by curve fitting utilizing PRISM to determine microtubule population turnover and half-life. This work uncovered the presence of more than just 2 microtubule populations within the mitotic spindle.

      • Aug 2012 - Jul 2019

      Identification and characterization of the mechanisms, pathways, and function of the protein G2 and S-phase Expressed 1 (GTSE1) during mitosis through the use of immunofluorescence techniques, confocal microscopy, live cell imaging, photoactivation assays, protein purification in bacteria, column chromatography, biochemical assays, western blot analysis, and molecular cloning. This work uncovered the role of GTSE1 in mediating chromosome alignment during mitosis. Additionally, identified GTSE1 as a potential chemotherapeutic target. Show less

    • Student
      • Jul 2019 - Jul 2019

      Focus: Gain an understanding of how science is conducted and commercialized in industry. Understand core business competencies necessary for the transition from academia to industry. Focus: Gain an understanding of how science is conducted and commercialized in industry. Understand core business competencies necessary for the transition from academia to industry.

    • United States
    • Research Services
    • 200 - 300 Employee
    • Student (Physiology Course)
      • Jun 2014 - Aug 2014

      7 week intensive research training course focused on molecular, biological, computational, and physical sciences 7 week intensive research training course focused on molecular, biological, computational, and physical sciences

    • Higher Education
    • 700 & Above Employee
    • Doctoral Candidate
      • Aug 2007 - Jun 2012

      Examined the mechanisms regulating mitotic checkpoint assembly and function through the use of protein purification in bacteria, insect, and mammalian cells, column chromatography, AKTA FPLC system, in vitro biochemical assays, binding kinetics assays, western blot analysis, and molecular cloning. This work first identified a direct interaction between MCC components BUBR1 and MAD2, and defined mechanisms resulting in MCC mediated APC/C inhibition. Examined the mechanisms regulating mitotic checkpoint assembly and function through the use of protein purification in bacteria, insect, and mammalian cells, column chromatography, AKTA FPLC system, in vitro biochemical assays, binding kinetics assays, western blot analysis, and molecular cloning. This work first identified a direct interaction between MCC components BUBR1 and MAD2, and defined mechanisms resulting in MCC mediated APC/C inhibition.

    • Higher Education
    • 700 & Above Employee
      • 2006 - 2007

      Examined the role of human Guanylate-Binding Protein-1 (hGBP-1) in paclitaxel resistance through the use of cell based assays following drug treatment and immunofluorescence.

      • 2005 - 2006

      Characterization of the intracellular localization of murine Guanylate-Binding Protein (mGBP) family members through transient expression in cells and immunofluorescence.

Education

  • The University of Toledo
    Doctor of Philosophy - PhD, Cellular and Molecular Biology
    2007 - 2012
  • The University of Toledo
    Biology/Biological Sciences, General
    2006 - 2007
  • Owens Community College
    Biology/Biological Sciences, General
    2005 - 2006
  • Walsh University
    Bachelor of Arts - BA, Marketing
    2000 - 2004

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