Yaxin Liu
Reserach Specialist at Incisive Genetics- Claim this Profile
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Bio
Experience
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Incisive Genetics
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Canada
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Biotechnology Research
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1 - 100 Employee
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Reserach Specialist
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Oct 2023 - Present
Vancouver, British Columbia, Canada
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New Beta Innovation Canada Limited
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Canada
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Pharmaceutical Manufacturing
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1 - 100 Employee
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Senior Research Associate
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Nov 2022 - May 2023
Canada As a senior research associate in the department of Clinical Projects & Development, I am responsible for planning, executing, and supervising research projects and experiments aimed at developing therapeutic drugs for diseases, particularly in the fields of oncology, neurology, and conditions related to ischemia and hypoxia. Highlights: - Developed in vitro models of ischemic stroke for efficient drug screening - Conducted screening to identify therapeutic peptides, leading to the… Show more As a senior research associate in the department of Clinical Projects & Development, I am responsible for planning, executing, and supervising research projects and experiments aimed at developing therapeutic drugs for diseases, particularly in the fields of oncology, neurology, and conditions related to ischemia and hypoxia. Highlights: - Developed in vitro models of ischemic stroke for efficient drug screening - Conducted screening to identify therapeutic peptides, leading to the discovery of potential candidates for stroke recovery - Utilized bioconjugation and ELISA techniques to validate targeting efficiency of drugs in vitro, ensuring accurate assessment of their efficacy and potential for further development - Assisted in the production and characterization of exosomes, facilitating the development of exosome-based therapies Show less
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University of Washington
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United States
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Higher Education
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700 & Above Employee
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Senior Reseach Fellow
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Jun 2017 - May 2022
Seattle, WA My postdoctoral research focuses on the differentiation, maturation, and proliferation of human induced pluripotent stem cell (iPSC)-derived cardiomyocytes, with the ultimate goal of advancing regenerative medicine. Highlights: - Established standard operating procedures (SOPs) for the culture of stem cells and the differentiation towards cardiomyocytes, ensuring a robust in vitro cardiomyocyte model - Developed and optimized cell-based assays to comprehensively characterize… Show more My postdoctoral research focuses on the differentiation, maturation, and proliferation of human induced pluripotent stem cell (iPSC)-derived cardiomyocytes, with the ultimate goal of advancing regenerative medicine. Highlights: - Established standard operating procedures (SOPs) for the culture of stem cells and the differentiation towards cardiomyocytes, ensuring a robust in vitro cardiomyocyte model - Developed and optimized cell-based assays to comprehensively characterize iPSCs and iPSC-derived cardiomyocytes - Characterized immune cells and immune responses in cell models, animal models and human clinical samples related to cardiovascular diseases, proving insights into underlying immune mechanisms and assessing the effectiveness of therapeutic candidates Show less
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State University of New York Upstate Medical University
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Hospitals and Health Care
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700 & Above Employee
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Graduate Research Assistant
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Aug 2010 - May 2017
Syracuse, New York, United States In parallel with receiving training in the foundation of knowledge, laboratory techniques and research skills of biochemistry and molecular biology, I have investigated the underlying pathogenic mechanism of a rare neurodegenerative disease, offering insights into therapeutic strategies for broader neurodegenerative conditions. Highlights: - Developed in vitro disease models, providing a reproducible model for studying disease mechanisms and advancing the understanding of disease… Show more In parallel with receiving training in the foundation of knowledge, laboratory techniques and research skills of biochemistry and molecular biology, I have investigated the underlying pathogenic mechanism of a rare neurodegenerative disease, offering insights into therapeutic strategies for broader neurodegenerative conditions. Highlights: - Developed in vitro disease models, providing a reproducible model for studying disease mechanisms and advancing the understanding of disease progression - Developed and optimized biochemical techniques for detecting protein misfolding, successfully revealing the underlying pathogenic mechanism - Two publications in high impact journals, a two-year predoctoral fellowship by the American Heart Association, and a scholarship award from SUNY Upstate Medical University for outstanding papers Show less
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East China Normal University
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China
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Higher Education
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500 - 600 Employee
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Student Research Assistant
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Sep 2006 - Jun 2009
Shanghai, China My master’s research project aimed to identity the coding sequence of an ion channel in chrysanthemum and explore its potential role in salt intolerance. Highlights: - Identified and characterized a novel gene encoding Na+/H+ antiporter from chrysanthemum (DmNHX1, GeneBank: EF396235.2) - Obtained a patent (CN101323855) for the application of DmNHX1 in enhancing salt tolerance, recognizing its potential as a valuable tool in plant breeding and cultivation
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Education
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SUNY Upstate Medical University
Doctor of Philosophy (PhD), Biochemistry and Molecular Biology -
East China Normal University
Master's Degree, Biochemistry and Molecular Biology -
East China Normal University
Bachelor's Degree, Biotechnology