Erika England
Biological Safety Specialist at University of North Carolina at Chapel Hill- Claim this Profile
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Topline Score
Bio
Credentials
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Shipping Infectious Substances (IATA and DOT)
EduwhereMar, 2015- Oct, 2024 -
IATA Dangerous Goods
EduwhereDec, 2014- Oct, 2024 -
DOT Hazardous Materials Transportation
EduwhereNov, 2014- Oct, 2024 -
RCRA Hazardous Waste Management for Generators
EduwhereNov, 2014- Oct, 2024 -
Adult First Aid, CPR, and AED
American Red CrossSep, 2015- Oct, 2024
Experience
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University of North Carolina at Chapel Hill
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United States
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Higher Education
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700 & Above Employee
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Biological Safety Specialist
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Jan 2016 - Present
• Alternate Responsible Official (ARO) and subject matter expert for regulatory compliance for the Federal Select Agent Program at UNC Chapel Hill • Manage CDC Select Agent program documentation for several select agent labs including Tier 1 labs • Main user and proficient in eFSAP for the University’s CDC registration • Helped write the CDC Plans (Biosecurity, Biosafety, Incident Response) in 2018 in accordance with regulations • Assist in review of lab SOPs, CDC plans, and medical… Show more • Alternate Responsible Official (ARO) and subject matter expert for regulatory compliance for the Federal Select Agent Program at UNC Chapel Hill • Manage CDC Select Agent program documentation for several select agent labs including Tier 1 labs • Main user and proficient in eFSAP for the University’s CDC registration • Helped write the CDC Plans (Biosecurity, Biosafety, Incident Response) in 2018 in accordance with regulations • Assist in review of lab SOPs, CDC plans, and medical surveillance SOP to continuously recognize biohazards, risk assessments, and mitigation of those hazards/risks • Conduct Select Agent inventories, inspections, transfers, and disposals • In charge of BSL-3 Lab decontaminations using vaporized hydrogen peroxide machines including writing SOPs, planning, and implementation of decons • Part of the Incident Management Team (IMT) that responded to UNC Wilmington after Hurricane Florence to assess the condition of the biological and chemical laboratories • Assisted UNC Hospital Infection Control to create a process to decontaminate N95 masks for reuse at the beginning of the pandemic. Created and validated the decontamination process with a VHP machine and taught Hospital personnel procedures for maintaining the program. • Perform lab inspections (BSL1-BSL3) to identify biological, chemical, radiological, and other safety hazards in order to assess risks and implement mitigation strategies. • Create online safety trainings and conduct classroom training for safety and regulatory compliance of university personnel. • Conduct incident investigations involving biological hazards and write reports that include mitigation strategies and/or any necessary corrective actions. • Core Team Member of the EHS Emergency Response Team responsible for responding to a variety of safety incidents on campus • Conduct interviews with pregnant researchers and recommend safety precautions for biological hazards as part of the University’s Conceptus program Show less • Alternate Responsible Official (ARO) and subject matter expert for regulatory compliance for the Federal Select Agent Program at UNC Chapel Hill • Manage CDC Select Agent program documentation for several select agent labs including Tier 1 labs • Main user and proficient in eFSAP for the University’s CDC registration • Helped write the CDC Plans (Biosecurity, Biosafety, Incident Response) in 2018 in accordance with regulations • Assist in review of lab SOPs, CDC plans, and medical… Show more • Alternate Responsible Official (ARO) and subject matter expert for regulatory compliance for the Federal Select Agent Program at UNC Chapel Hill • Manage CDC Select Agent program documentation for several select agent labs including Tier 1 labs • Main user and proficient in eFSAP for the University’s CDC registration • Helped write the CDC Plans (Biosecurity, Biosafety, Incident Response) in 2018 in accordance with regulations • Assist in review of lab SOPs, CDC plans, and medical surveillance SOP to continuously recognize biohazards, risk assessments, and mitigation of those hazards/risks • Conduct Select Agent inventories, inspections, transfers, and disposals • In charge of BSL-3 Lab decontaminations using vaporized hydrogen peroxide machines including writing SOPs, planning, and implementation of decons • Part of the Incident Management Team (IMT) that responded to UNC Wilmington after Hurricane Florence to assess the condition of the biological and chemical laboratories • Assisted UNC Hospital Infection Control to create a process to decontaminate N95 masks for reuse at the beginning of the pandemic. Created and validated the decontamination process with a VHP machine and taught Hospital personnel procedures for maintaining the program. • Perform lab inspections (BSL1-BSL3) to identify biological, chemical, radiological, and other safety hazards in order to assess risks and implement mitigation strategies. • Create online safety trainings and conduct classroom training for safety and regulatory compliance of university personnel. • Conduct incident investigations involving biological hazards and write reports that include mitigation strategies and/or any necessary corrective actions. • Core Team Member of the EHS Emergency Response Team responsible for responding to a variety of safety incidents on campus • Conduct interviews with pregnant researchers and recommend safety precautions for biological hazards as part of the University’s Conceptus program Show less
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Novan, Inc.
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United States
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Pharmaceutical Manufacturing
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1 - 100 Employee
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Assistant Scientist
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Dec 2014 - Oct 2015
- Analyze drug product, intermediates and drug substance to determine stability of products and substances. - Perform research and development (R&D) using Karl Fischer, viscometer, pH, Nitric Oxide Analyzer (NOA), high performance liquid chromatography (HPLC), and Fourier transform infrared spectroscopy (FT-IR) to maintain compliance with Good Manufacturing Process (GMP) standards. - Test GMP waste streams for pH and nitric oxide to ensure levels are within profile specifications. -… Show more - Analyze drug product, intermediates and drug substance to determine stability of products and substances. - Perform research and development (R&D) using Karl Fischer, viscometer, pH, Nitric Oxide Analyzer (NOA), high performance liquid chromatography (HPLC), and Fourier transform infrared spectroscopy (FT-IR) to maintain compliance with Good Manufacturing Process (GMP) standards. - Test GMP waste streams for pH and nitric oxide to ensure levels are within profile specifications. - Serve as Safety Committee member assisting in monitoring incident reports and corrective actions, instituting procedures for safe work practices, and conducting chemical inventory. - Analyze non-clinical plasma samples using HPLC and Graphite Furnace Atomic Absorption (GFAA) to meet Good Laboratory Practice (GLP) standards. - Coordinated North Carolina Department of Environment and Natural Resources (NCDNER) audit of facility, corrected violations and assisted in drafting timely response letter to maintain accreditation. - Initiated and assisted in liaison with environmental consultants to create waste management program and transition to large quantity generator to minimize environmental impact and reduce costs. - Generate, update, and manage chemical waste profiles for waste streams saving over $3K. - Maintain waste manifests, personnel certifications, and other required documentation to comply with Resource Conservation and Recovery Act (RCRA) and Environmental Protection Agency (EPA) regulations. - Conduct regular safety checks of labs and satellite areas to ensure waste is being properly labeled and disposed. - Ship drug product / substance, chemicals, and samples while adhering to proper International Air Transport Association (IATA) and Department of Transportation (DOT) regulations. - Utilize cold chain shipping with CREDO boxes and dry ice to properly ship material while maintaining a constant temperature.
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Lab Technician (Contractor)
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Sep 2014 - Dec 2014
Analyzed non-clinical plasma samples with GFAA to maintain compliance with GLP standards. Conditioned HPLC and GFAA instruments and materials to assist other scientists.
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North Carolina State University
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United States
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Higher Education
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700 & Above Employee
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Research Technician
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Sep 2012 - Sep 2014
-Managed daily lab operations by ordering, receiving, and inventorying lab supplies, chemicals, and training students in lab safety. -Instructed graduate and undergraduate students in experimental procedures and instrument use to gain necessary skills and competencies. -Developed method of Sonication protocol for cell lysate step in protein purification to replace French Press while out of service. -Conducted Alanine mapping of prodomain by cloning, purifying, and expressing 28… Show more -Managed daily lab operations by ordering, receiving, and inventorying lab supplies, chemicals, and training students in lab safety. -Instructed graduate and undergraduate students in experimental procedures and instrument use to gain necessary skills and competencies. -Developed method of Sonication protocol for cell lysate step in protein purification to replace French Press while out of service. -Conducted Alanine mapping of prodomain by cloning, purifying, and expressing 28 caspase-3 mutant proteins to analyze effects of binding region on prodomain to allosteric site after activation and cleavage resulting in detectable levels of protein stabilization with prodomain binding. -Purified and expressed over 30 caspase-3 mutants and cloned 8 more with mutations in inter-subunit linker region with results from SDS gels and western blots published in professional journal. -Completed Cycloheximide Chase experiments in cell culture for several caspase proteins with active site mutations in order to determine stability, activity, and half-life using fluorometer. -Executed Phage Display experiments to identify protein-protein interactions between amyloid beta and caspase-3 proteins. Created 4 libraries for screening and confirmed binding using ELISA as part of larger project to map functionally important “hot spots” on caspases for rational design of therapeutic inhibitors to prevent neurodegeneration. -Coordinated regular Safety and Environmental Health and Safety inspections of laboratory, and personally corrected violations or reported to facilities via work requests for prompt correction. -Served as instrumental person in inventorying, reorganizing and electronically cataloging all sequenced DNA, primers, glycerol stocks, reagents and lab supplies, which improved efficiency and ease of use. -Performed maintenance, troubleshooting, and repair of lab equipment to maintain smooth lab operations. Show less -Managed daily lab operations by ordering, receiving, and inventorying lab supplies, chemicals, and training students in lab safety. -Instructed graduate and undergraduate students in experimental procedures and instrument use to gain necessary skills and competencies. -Developed method of Sonication protocol for cell lysate step in protein purification to replace French Press while out of service. -Conducted Alanine mapping of prodomain by cloning, purifying, and expressing 28… Show more -Managed daily lab operations by ordering, receiving, and inventorying lab supplies, chemicals, and training students in lab safety. -Instructed graduate and undergraduate students in experimental procedures and instrument use to gain necessary skills and competencies. -Developed method of Sonication protocol for cell lysate step in protein purification to replace French Press while out of service. -Conducted Alanine mapping of prodomain by cloning, purifying, and expressing 28 caspase-3 mutant proteins to analyze effects of binding region on prodomain to allosteric site after activation and cleavage resulting in detectable levels of protein stabilization with prodomain binding. -Purified and expressed over 30 caspase-3 mutants and cloned 8 more with mutations in inter-subunit linker region with results from SDS gels and western blots published in professional journal. -Completed Cycloheximide Chase experiments in cell culture for several caspase proteins with active site mutations in order to determine stability, activity, and half-life using fluorometer. -Executed Phage Display experiments to identify protein-protein interactions between amyloid beta and caspase-3 proteins. Created 4 libraries for screening and confirmed binding using ELISA as part of larger project to map functionally important “hot spots” on caspases for rational design of therapeutic inhibitors to prevent neurodegeneration. -Coordinated regular Safety and Environmental Health and Safety inspections of laboratory, and personally corrected violations or reported to facilities via work requests for prompt correction. -Served as instrumental person in inventorying, reorganizing and electronically cataloging all sequenced DNA, primers, glycerol stocks, reagents and lab supplies, which improved efficiency and ease of use. -Performed maintenance, troubleshooting, and repair of lab equipment to maintain smooth lab operations. Show less
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North Carolina State University
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United States
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Higher Education
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700 & Above Employee
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Research Assistant
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Aug 2011 - Jun 2012
• Employed Recombinant DNA techniques to clone several mutant and wild type Clostridium ljungdahlii Alcohol Dehydrogenase genes into E.coli cloning and expression vectors • Performed protein isolation and purification using small scale expressions, column chromatography, western blots, SDS-PAGE, and activity assays on recombinant proteins • Prepared stock solutions, antibiotics, media, and other reagents for laboratory use • Conducted troubleshooting during experiments and adjusted… Show more • Employed Recombinant DNA techniques to clone several mutant and wild type Clostridium ljungdahlii Alcohol Dehydrogenase genes into E.coli cloning and expression vectors • Performed protein isolation and purification using small scale expressions, column chromatography, western blots, SDS-PAGE, and activity assays on recombinant proteins • Prepared stock solutions, antibiotics, media, and other reagents for laboratory use • Conducted troubleshooting during experiments and adjusted protocols accordingly
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Biochemistry Teaching Assistant
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Jan 2011 - May 2012
• Tutored and assisted students individually or in groups of 50+ students to help them master assignments and to reinforce learning concepts presented by instructor • Graded exams, quizzes and assignments for 200+ students every semester
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North Carolina State Laboratory of Public Health
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Raleigh-Durham, North Carolina Area
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Bioterrorism and Emerging Pathogens Intern
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Jun 2010 - Aug 2010
• Worked on a geomapping program which integrated lab test results to a mapping program that identified high concentrations of sample submissions from clinics • Performed Limit of Detection tests using PCR with serial dilutions of several pathogens • Conducted Quality Control and Statistics by data mining through six years of lab results in the LIMS system to create Levey-Jennings charts • Currently hold a FBI clearance for handling select pathogens • Certification and experience in… Show more • Worked on a geomapping program which integrated lab test results to a mapping program that identified high concentrations of sample submissions from clinics • Performed Limit of Detection tests using PCR with serial dilutions of several pathogens • Conducted Quality Control and Statistics by data mining through six years of lab results in the LIMS system to create Levey-Jennings charts • Currently hold a FBI clearance for handling select pathogens • Certification and experience in a BSL-3 laboratory Show less • Worked on a geomapping program which integrated lab test results to a mapping program that identified high concentrations of sample submissions from clinics • Performed Limit of Detection tests using PCR with serial dilutions of several pathogens • Conducted Quality Control and Statistics by data mining through six years of lab results in the LIMS system to create Levey-Jennings charts • Currently hold a FBI clearance for handling select pathogens • Certification and experience in… Show more • Worked on a geomapping program which integrated lab test results to a mapping program that identified high concentrations of sample submissions from clinics • Performed Limit of Detection tests using PCR with serial dilutions of several pathogens • Conducted Quality Control and Statistics by data mining through six years of lab results in the LIMS system to create Levey-Jennings charts • Currently hold a FBI clearance for handling select pathogens • Certification and experience in a BSL-3 laboratory Show less
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Substitute Teacher
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Aug 2008 - Aug 2009
Substitute teacher for over 140 hours of chemistry lectures, chemistry labs, and math classes from remedial level to business calculus.
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Student Tutor
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Feb 2008 - Aug 2009
Tutored over 800 hours in chemistry, biology, math, and physics in the College's Math Lab.
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Center for Marine Science, UNC Wilmington
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Wilmington, North Carolina Area
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Summer Internship
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Jun 2007 - Aug 2007
Assisted in the process of growing dinoflagellate cultures and isolating organic compounds from those cultures using several extraction methods. Purified the organic compounds through HPLC machines. Prepared samples for Mass Spectrometer and NMR analysis. Conducted various assays with serial dilutions of four of the organic compounds. My research contributed to a poster presented at the 5th European Conference on Marine Natural Products, September 2007. Assisted in the process of growing dinoflagellate cultures and isolating organic compounds from those cultures using several extraction methods. Purified the organic compounds through HPLC machines. Prepared samples for Mass Spectrometer and NMR analysis. Conducted various assays with serial dilutions of four of the organic compounds. My research contributed to a poster presented at the 5th European Conference on Marine Natural Products, September 2007.
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Education
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2017 - 2023
University of North Carolina at Chapel Hill
Master of Public Health - MPH -
2009 - 2012
NC State University
Bachelor’s Degree, Biochemistry and Molecular Biology -
2005 - 2008
Coastal Carolina Community College
Associate's degree, Biology/Biological Sciences, General
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