Experience

TwinStrand Biosciences

• United States
• Biotechnology Research
• 1 - 100 Employee

• Senior Bioinformatics Scientist

  • Aug 2023 - Present

  • Improve and test genomic pipelines and internal tools like R packages to facilitate analysis of Duplex-Sequencing data for the detection of ultra-rare mutations. • Lead connections with external partners to create collaborations to improve in-house analysis. • Lead client NGS sequencing data analysis and troubleshooting. Create analysis, interpretation, and graphical representation of mutagenesis, genotoxicity, and mixture deconvolution data using a combination of custom-developed… Show more • Improve and test genomic pipelines and internal tools like R packages to facilitate analysis of Duplex-Sequencing data for the detection of ultra-rare mutations. • Lead connections with external partners to create collaborations to improve in-house analysis. • Lead client NGS sequencing data analysis and troubleshooting. Create analysis, interpretation, and graphical representation of mutagenesis, genotoxicity, and mixture deconvolution data using a combination of custom-developed software or scripts and open-source tools. • Work with the bioinformatics team, R&D scientists, and software developers in a rapidly growing genomics start-up company. • Design custom panels and automate custom panel design creation for targeted DNA-seq applied for MRD detection. • Work closely with internal teams, partners, and customers to generate reproducible data and present the results that translate complex ideas into relevant and intuitive explanations. • Author conference abstracts in collaboration with leading academic and industry partners.

• Bioinformatics Scientist II

  • Apr 2022 - Sep 2023

• Bioinformatics Scientist

  • Jan 2021 - Apr 2022



Agendia

• United States
• Biotechnology
• 100 - 200 Employee

• Bioinformatics Scientist II

  • Jan 2020 - Jan 2021

  •Perform data analysis in molecular diagnostics of NGS and microarray data using R and Python scripts. •Responsible for the Quality Control model and monitoring of NGS diagnostic data. •Provide commercial support for external parties, performing investigations and data analysis of their NGS runs using Agendia’s NGS analysis pipeline. •Help internal and external parties on NGS troubleshooting. •Organize and clean data to be transfered to clinical trials. •Perform and request… Show more •Perform data analysis in molecular diagnostics of NGS and microarray data using R and Python scripts. •Responsible for the Quality Control model and monitoring of NGS diagnostic data. •Provide commercial support for external parties, performing investigations and data analysis of their NGS runs using Agendia’s NGS analysis pipeline. •Help internal and external parties on NGS troubleshooting. •Organize and clean data to be transfered to clinical trials. •Perform and request software updates, and participate in method and software validation.

• Bioinformatician I

  • Feb 2019 - Jan 2020

  Irvine, California



UC Irvine

• United States
• Higher Education
• 700 & Above Employee

• Graduate Student Researcher

  • Sep 2013 - Jun 2019

  Irvine, California, United States Ph.D. Program in Pharmacological Science, working on Computational Chemistry. • Performed solvation free energy calculations of 642 small molecules, with experience in 4 different software (GROMACS, OpenEye toolkit, OpenMM, Amber). • Used bioinformatics tools and structure-based search methods to find GTP aptamers in BLAST database (Luptak Lab). • Worked on parallel molecular dynamics simulations of protein and macrocyclic peptide engineering using GROMACS. • Applied 3… Show more Ph.D. Program in Pharmacological Science, working on Computational Chemistry. • Performed solvation free energy calculations of 642 small molecules, with experience in 4 different software (GROMACS, OpenEye toolkit, OpenMM, Amber). • Used bioinformatics tools and structure-based search methods to find GTP aptamers in BLAST database (Luptak Lab). • Worked on parallel molecular dynamics simulations of protein and macrocyclic peptide engineering using GROMACS. • Applied 3 different computational docking software (AutoDock Vina, OEDocking, and Schrödinger) and shape similarity technique to study structure-activity relationships of lissoclimide compounds (translation inhibitors) in ribosome in collaboration with Vanderwal Lab. • Worked collaboratively on code development of a chemical perception tool in the innovative Open Force Field Group [openforcefield.org] to sample atom types and fragment types using Monte Carlo optimization and statistical Bayesian Inference. Show less



USP - Universidade de São Paulo

• Brazil
• Higher Education
• 700 & Above Employee

• Graduate Student Researcher

  • Feb 2011 - May 2013

  São Paulo e Região, Brasil Master's degree in Nuclear Technology - Validation of Analytical Methods and Procedures. • Developed the research at the Brazilian Nuclear and Energy Research Institute facilities • Worked on the synthesis and production of a F-18 radiopharmaceutical for cancer diagnosis • Elaborated standard operating procedures • Adapted and developed analytical methods for quality control • Developed documentation for quality assurance of a new radiopharmaceutical drug (experience with… Show more Master's degree in Nuclear Technology - Validation of Analytical Methods and Procedures. • Developed the research at the Brazilian Nuclear and Energy Research Institute facilities • Worked on the synthesis and production of a F-18 radiopharmaceutical for cancer diagnosis • Elaborated standard operating procedures • Adapted and developed analytical methods for quality control • Developed documentation for quality assurance of a new radiopharmaceutical drug (experience with FDA 21 CRF and USP-NF) • Worked with tumor models in mouse, drug biodistribution, cell internalization, in vitro toxicity tests, PET/CT images

• Teaching Assistant

  • Jul 2011 - Dec 2011

  São Paulo e Região, Brasil



Grupo Educacional Sequencial

• Brazil
• Higher Education
• 100 - 200 Employee

• Professor

  • Jul 2011 - Dec 2011

  São Paulo e Região, Brasil • Professor in charge of the pharmaceutical formulation development course in the Pharmacy Technician Program • Taught introductory concepts in pharmaceutical formulation development • Prepared and proctored quizzes and exams • Taught laboratory practice in pharmaceutical formulation



IPEN

• Brazil
• Government Administration
• 300 - 400 Employee

• Trainee

  • Jun 2010 - Dec 2010

  São Paulo e Região, Brasil • Rotated in different areas in the IPEN Radiopharmacy Center (National Nuclear Energy Comission) • Worked in quality control and R&D of radiopharmaceuticals laboratories • Elaborated validation protocol • Participated in validation process and production routine.



Universidade Estadual de Maringá

• Brazil
• Higher Education
• 700 & Above Employee

• Undergraduate Student Researcher

  • Mar 2008 - Jul 2010

  Maringá e Região, Brasil Researcher at Department of Morphological Science, in Anatomy and Histology field, with PIBIC scholarship from CNPq.