Experience

New York Structural Biology Center

• United States
• Research Services
• 1 - 100 Employee

• Scientist

  • Jan 2017 - Present

  New York, NY March 2020 - Present: Scientist & Training Liasion, National Center for CryoEM Access and training at the Simons Electron Microscopy Center (SEMC). In this role I support visiting scientists conducting embedded training as part of the NIH Common Fund CryoEM initiative. I collaborate with scientists across the NIH CryoEM program to develop training materials for cryoEM trainees. I am also involved in establishing electron diffraction methods as a routine technique at SEMC. Jan 2017 - Feb… Show more March 2020 - Present: Scientist & Training Liasion, National Center for CryoEM Access and training at the Simons Electron Microscopy Center (SEMC). In this role I support visiting scientists conducting embedded training as part of the NIH Common Fund CryoEM initiative. I collaborate with scientists across the NIH CryoEM program to develop training materials for cryoEM trainees. I am also involved in establishing electron diffraction methods as a routine technique at SEMC. Jan 2017 - Feb 2020: Scientist, Special Projects Group. As a scientist in this group, I carried out independently funded research projects using structural biology to understand underlying mechanisms of human disease in multiple areas. In this small group I was involved in all aspects of the work, including grant writing, experimental design and implementation, performing experiments and supervising research assistants, data analysis and manuscript writing. Show less



Harvard University

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral Fellow

  • Aug 2013 - Dec 2016

  Cambridge, MA In the Gaudet Lab, I used a structural approach to understand how transport across cellular membranes is regulated by two families of proteins: first, TRP ion channels, and second, SLC family transporters. I used lipidic cubic phase techniques to obtain X-ray crystal structures of a divalent metal transporter. These structures will help us understand how conformational changes in this family of transporters controls transport for a specific subset of metal ions into the cell.



Massachusetts Institute of Technology

• United States
• Higher Education
• 700 & Above Employee

• Graduate Research Assistant

  • Sep 2007 - Jun 2013

  Cambridge, MA In my dissertation research, I used crystallographic studies as a primary tool in combination with other biophysical techniques to study the allosteric regulation of the E. coli class Ia ribonucleotide reductase (RNR). As the sole provider of de novo deoxyribonucleotides in the cell, RNRs are essential for DNA replication and repair and have been successful targets for cancer therapies. I solved structures of E. coli RNR in multiple states (including the first E. coli holoenzyme) with different… Show more In my dissertation research, I used crystallographic studies as a primary tool in combination with other biophysical techniques to study the allosteric regulation of the E. coli class Ia ribonucleotide reductase (RNR). As the sole provider of de novo deoxyribonucleotides in the cell, RNRs are essential for DNA replication and repair and have been successful targets for cancer therapies. I solved structures of E. coli RNR in multiple states (including the first E. coli holoenzyme) with different sets of bound allosteric effectors and/or substrates that illustrate how small molecule effectors cause both small-scale conformational changes in the active site that determine substrate preference and large-scale changes in oligomeric state that regulate the overall activity of the enzyme. Solution studies revealed how effector binding shifts the equilibrium distribution of oligomerization states observed in these crystal structures. From these data we obtained an atomic-level description of RNR regulation that clarified (and was consistent with) over 50 years worth of biochemical data on the E. coli enzyme. Show less



Novartis

• Switzerland
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Intern

  • Jun 2009 - Sep 2009

  Cambridge, MA



Study Smarter, LLC

• Tutor

  • 2007 - 2007

  Oakland, CA Tutored Oakland area high school students in a one-on-one setting. Tutored in multiple math and science subjects as well as general study skills and time management.



University of California, Berkeley

• United States
• Higher Education
• 700 & Above Employee

• Undergraduate Research Assistant

  • Jul 2005 - Dec 2006

  Berkeley, CA I investigated the role of the unique cell surface glycan, polysialic acid (PSA), in immune cells using immunolabeling and flow cytometry and phenotyping of a PSA-null mouse.