Experience

Pharmaron

• China
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Bioanalytical Scientist II (Lead Scientist), LC-MS/MS

  • Jan 2023 - Present

  • Oversees the execution of LC-MS/MS small molecule and large molecule assay/method development, validation, and sample analysis activities, and serves as main point of contact with sponsors for all assigned study related deliverables. • Hosts regularly scheduled client teleconferences throughout the course of the study. • Assists in reviewing the laboratory manual, clinical protocol, data transfer agreement and other miscellaneous documents prepared by sponsor and/or clinic. • Oversees the project by designing the experimental approach, overseeing the experimental execution, collating, and interpreting scientific data and generating study reports, working in close co-operation with study sponsors at all stages. • Working with other laboratory staff to progress study-specific experimental work and, as necessary, to support non-study-specific laboratory duties. • Works closely with the sample management team in sample login as well as transfer, storage, and disposal of the study samples. • Works closely with bioanalytical report writer in draft preparation, review, and finalization of the study report. • Work closely with Quality Assurance team in scheduling study data and report audit, critical phase inspection and collaborating with team members in addressing each of the study findings. • Assist in archiving study related documentation, including email correspondence and electronic raw data files.• Provide scientific and technical support to colleagues in the Business Development group, as required. This may involve participation in client visits, both inbound and outbound. • Attends and presents at Scientific Conferences.

• Bioanalytical Scientist I, LC-MS/MS

  • Dec 2021 - Dec 2022

  • Responsible for performing the LC-MS/MS bioanalysis of various drug molecules (ranging fromsmall to large), biomarkers, and peptides. Also, responsible for resolving issues while working withdrug molecule that are prone to degradation, binding, and interference.• Develop and validate (GLP) robust and reproducible LC-MS/MS method to support pharmacokinetics (PK) analysis of investigational drug developed for various therapeutic indication. • Prepare data tables and reports within LIMS. • Assist in training personnel in the operation, maintenance, and troubleshooting of equipment.• Control appropriate bioanalytical portion of studies by designing the experimental approach, overseeing the experimental execution, collating, and interpreting scientific data and generating study reports, working in close co-operation with study sponsors at all stages.• Carry out laboratory tasks, work with other laboratory staff to progress study-specific experimental work and, as necessary, to support non-study-specific laboratory duties.• Provide scientific and technical support to colleagues and clients.



Baylor College of Medicine

• United States
• Higher Education
• 700 & Above Employee

• Research Scientist (Analytical Chemistry & Metabolomics)

  • Feb 2020 - Dec 2021

  Baylor College of Medicine is a private stand-alone health sciences university within the Texas Medical Center (the world's largest medical center), and is one of the top 25 medical schools in the country. Worked as a NIH funded postdoctoral researcher under the supervision of Prof. Dr. Arun Sreekumar in the Department of Molecular and Cellular Biology. Key Contributions as a Chemist: • Worked on the development of a plasma based metabolomic biomarker panel for the early stage diagnosis of prostate cancer using mass spectrometry (QQQ LC-MS/MS). Also, worked on installing and operating an Opentrons automation platform and used it to validate the assay developed for the biomarker panel. • Developed a first-in-field MSI technique combining AP-MALDI ion source with a QQQ-MS/MS to evaluate the spatial distributions of several metabolites in fresh-frozen and FFPE tissues in a targeted manner. • Specialized in the development of LC-MS/MS methods for the determination and quantitation of different metabolites like amino acids, sugars, fatty acids-related to the glycolysis, pentose phosphate, and TCA (citric acid cycle) pathways, and also including bile acids, lipids, steroids in complex biological matrices such as plasma, serum, urine, tissues, cell lines, feces. • Hands on experience with mass spectrometry based invivo and invitro metabolomic flux analysis with different 13-C labeled energy sources (such as glucose). • Proficient in bioanalytical assay preparation and hands on experience in quantifying absolute concentrations of metabolites by Biocrates p180 kit using QTRAP 6500 LC/MS/MS system. • Collaborated with a team of PhD molecular biologists and other postdocs for several projects, • Gained strong ability to prioritize responsibilities, multi-task, and remain flexible and be motivated to work in a fast paced environment.



American Chemical Society

• United States
• Non-profit Organizations
• 700 & Above Employee

• Project SEED Camp Mentor

  • Jun 2021 - Jul 2021

  Responsibilities: - Worked closely with a Camp Manager. - Shared research, taught and introduced students on the topic of "mass spectrometry and it's applications" through a presentation. - Approached this opportunity with the idea that students will present the information they have learned at the end of the summer. Responsibilities: - Worked closely with a Camp Manager. - Shared research, taught and introduced students on the topic of "mass spectrometry and it's applications" through a presentation. - Approached this opportunity with the idea that students will present the information they have learned at the end of the summer.



The University of Texas at Arlington

• United States
• Higher Education
• 700 & Above Employee

• Research Chemist

  • Jan 2016 - Dec 2019

  Research Work:Organic and Analytical Chemistry: Design, synthesis, and mechanistic study of transition metal complexes as catalysts for the functionalization of inert C-H and C=C bonds; activation of small molecules; identify key reaction intermediates & study reaction mechanism; metal-ligand and metal-metal structure, bonding, and reactivity studies.Expertise:• Designed and developed several new practical synthetic routes for the synthesis of small molecule targets, complex intermediates, metal complexes and novel compound identification and purification of compound of interest using HPLC and GC-MS, LC-MS, and GC-VUV for separation and identification of organic small molecules and also NMR & FT-IR & UV for structure confirmation. • Extensive experience to communicate results through effective written documentation and oral presentations. • Strong project management & problem-solving skills with experience in facilitating cross-functional collaborations and detailed planning leading to the successful completion of several research projects, and resulting in 8 peer-reviewed publications, 2 funded grant proposals and also achieved me the outstanding Ph.D. student award. • Strong experience to execute technical projects, including conducting laboratory experiments at the bench and directing the work to junior technicians including undergraduate and graduate students.

• Research And Teaching Assistant

  • Aug 2015 - Jul 2016

  I have served in various teaching roles at UT-Arlington since beginning graduate studies in 2015 and simultaneously did research in the laboratory. I have managed both of them equally well. I have organized, taught and conducted laboratory classes for general chemistry labs, which include teaching 2 sections of 25 students per semester and holding regular office hours, both required and voluntary. I have also served as a TA for organic chemistry lab for 2 sections of 18 students per semester, along with holding regular office hours, both required and voluntary. During the period as a teaching assistant, I have also involved in weekly discussion sessions with lab coordinator, writing and grading quizzes, and proctoring and grading exams.



Baylor College of Medicine

• United States
• Higher Education
• 700 & Above Employee

• Research Intern

  • May 2019 - Aug 2019

  1. Contributed to the initial stages of the development of metabolic markers plasma for early detection of prostate cancer and exposed to the biomarker development pipeline. 2. Learned methods for metabolite extraction from clinical samples. 3. Developed new LC-MS, GC-MS and HPLC-MS methods for quantification of cancer-associated metabolites in biofluids. 4. Strong experience in working with single and multichannel pipettors, Eppendorf tubes, 24-, 48- and 96-well plates, vortexing, centrifugal evaporators, tumble stirrers, and hot plate stirrers, incubators, and heater/cooler shakers, which are commonly used in high-throughput experimentation (HTE) experiments in pharmaceutical companies. 5. Exposed to real-time PCR instrument, western blotting, and cell culture experiments and learned how to work on them. 6. Provided direct supervision to high school students.



National Institute of Science Education and Research

• Higher Education
• 300 - 400 Employee

• Master's Research

  • Aug 2013 - Jun 2015

  Thesis: Synthesis of highly luminescent phosphazene-based boron – difluoride β-diketonate materials and pyrazole-based π-conjugated frameworks. Summary: Developed several novel organic compounds (phosphazene-based boron difluoride β-diketonates with two, four and six substitutions & boron inserted pyrazole-based π-conjugated frameworks) which contain p-block element components in their structure for advancements in organic light-emitting diode (OLED) technologies and molecular electronics. • Strong experience in working with thin-layer chromatography, column chromatography, vacuum evaporation, recrystallization & distillation techniques, UV/Vis, and fluorescence spectroscopy. • Good knowledge and experience in electrochemistry where I have used cyclic voltammetry for studying the electrochemical properties (potentials) of luminescent materials.



Syngene International Limited

• India
• Research Services
• 700 & Above Employee

• Research And Development Intern - Discovery Chemistry

  • May 2014 - Aug 2014

  Advisor: Dr. Arunkanti Sarkar, Senior Scientific Manager at Syngene International Ltd (Biocon) Project Title: "Synthesis of Chiral based β-Ketiminate Ligands for epoxide/CO2 Copolymerization" Summary: • Synthesized several chiral organic compounds and developed their metal complexes used for epoxide/CO2 copolymerization to afford polycarbonates. • Experienced in scaling up the laboratory processes to produce pilot plant and production quantities of organic compounds in accordance with cGMP requirements. • Experienced in writing development reports on the synthesis and scale-up projects as per cGMPs. • Experience in handling “GRAZE Column Chromatography” (automatic column).



Indian Institute of Science Education and Research (IISER), Pune

• India
• Research Services
• 700 & Above Employee

• Summer Research Intern

  • May 2012 - Jul 2012

  Advisor: Dr. R. Boomi Shankar, Associate Professor, Division of Chemistry at IISER Pune. Project Title: “Peripheral Functionalization of Siloxane and Their Reactivity Studies” Summary: • General reactions conditions for the synthesis of diethoxydichlorosilanes from tetraethoxysilane and acetyl chloride in presence of aluminum chloride have been developed. • Developed the formation of a novel tetrasiloxane containing bi-functional peripheral groups. • First Experience in the usage of Schlenk-Line technique. • Project was a part of SSP (Summer Student Programme) – 2012, conducted by IISER-Pune once every year for selected students.



National Institute of Science Education and Research

• Higher Education
• 300 - 400 Employee

• Summer Research Intern

  • May 2011 - Jul 2011

  Advisor: Dr. S. Peruncheralathan, Reader-F, School of Chemical Sciences, NISER, Bhubaneswar. Project title: “Synthesis of Chiral Sulfur Ligands” Summary: • Developed the synthesis of the chiral sulfur ligand “BINSH” from BINOL. • Hands on experience with flash column chromatography and FTIR-spectrometry. Advisor: Dr. S. Peruncheralathan, Reader-F, School of Chemical Sciences, NISER, Bhubaneswar. Project title: “Synthesis of Chiral Sulfur Ligands” Summary: • Developed the synthesis of the chiral sulfur ligand “BINSH” from BINOL. • Hands on experience with flash column chromatography and FTIR-spectrometry.