Experience

Labor Berlin - Charité Vivantes GmbH

• Germany
• Hospitals and Health Care
• 100 - 200 Employee

• Bioinformatics Scientist

  • Jul 2017 - Present

  Coordination of Next Generation Sequencing (NGS) data analysis in an accredited medical diagnostics laboratory: * Human Genetics (Prof. Mundlos) - QC, QA, Germline Variant Calling, Variant Interpretation, Database Development * Microbiology (Prof. Diefenbach) - QC, QA, Amplicon- and WGS-based Detection of Pathogens, Microbiome Analysis * Virology (Prof. Drosten) - QC, Amplicon- and WGS-based NGS Data Analysis * Haematology / Oncology (Prof. Bullinger) - QC, Somatic Variant Calling, Database Development * IT - Administration of _in house_ Cluster System & Variant Database * Translation of Innovative Research Finding into Routine Diagnostics - Validation & Feasibility Analyses Show less



Max Planck Institute for Molecular Genetics (MPI-MG)

• Germany
• Research Services
• 100 - 200 Employee

• Post-Doc in Computational Epigenomics

  • Apr 2017 - Jun 2017

  Robust Normalization of ChIP-seq Data to Study the _in vivo_ Formation of Constitutive and Facultative Heterochromatin.Identification and Characterization of Cis-regulatory Elements (Enhancers) in Limb Development in STARR-seq Data.Characterization of DNA Accessibility at Differentially Active Genes in Rare T cell Sub-Types with ATAC-seq Data.

• PhD Student in Computational Epigenomics

  • May 2012 - Mar 2017

  High-throughput Next Generation Sequencing Data Analysis and integration with machine learning techniques. Hypothesis driven research in promoter-resided transcriptional regulation in the context of chromatin and genome organization. Analysis of 3rd generation sequencing data



Max Planck Institute for Molecular Genetics

• Berlin

• Diploma Thesis

  • Apr 2011 - Jan 2012

  In my Diploma Thesis I studied epigenetic marks of human tissue-specific gene promoters. I classified genes by differential expression patterns across 16 Human tissues samples (RNA-seq). On a genome-scale I characterized the so classified genes based on sequence characteristics and epigenetic modifications (ChIP-seq). To efficiently mine data, I developed tools in R and C++, such that I could test the hypothesis of epigenetic differences between housekeeping and tissue-specific gene regulation. Housekeeping genes are controlled by promoters which are ubiquitously initiated/accessible. Their gene transcription is regulated at the transition to transcriptional elongation. On the contrary, tissue-specific genes are controlled at the stage of transcriptional initiation. Show less



University of Jena

• Higher Education
• 200 - 300 Employee

• Student Research Assistant

  • Aug 2010 - Mar 2011

  JAVA Programming Tasks within the Sirius2 framework for mass spectrometry analysis. JAVA Programming Tasks within the Sirius2 framework for mass spectrometry analysis.



Massey University

• New Zealand
• Higher Education
• 700 & Above Employee

• Student Research Assistant

  • Oct 2009 - Feb 2010

  Programming and analysis tasks to model third dimension genomic interactions in S.cerevisiae by integration of novel experimental and in silico techniques. Programming and analysis tasks to model third dimension genomic interactions in S.cerevisiae by integration of novel experimental and in silico techniques.



University of Jena

• Higher Education
• 200 - 300 Employee

• Student Research Assistant

  • Nov 2008 - Sep 2009

  JAVA (J2EE, JPA, Eclipselink) Programming Tasks for EPoS for analysis on phylogenetic trees. JAVA (J2EE, JPA, Eclipselink) Programming Tasks for EPoS for analysis on phylogenetic trees.