Molly Smith

Scientist II at Poseida Therapeutics, Inc.
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Contact Information
us****@****om
(386) 825-5501
Location
San Diego, California, United States, US

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Experience

    • United States
    • Biotechnology Research
    • 200 - 300 Employee
    • Scientist II
      • Oct 2021 - Present

    • United States
    • Biotechnology Research
    • 100 - 200 Employee
    • Scientist
      • Sep 2019 - Oct 2021

      As part of the Immune Cell Therapy team, I developed robust differentiation and characterization methods for human induced pluripotent stem cell (iPSC)-derived immune cell types for the utility in CAR-T and other cell therapies. As part of the Immune Cell Therapy team, I developed robust differentiation and characterization methods for human induced pluripotent stem cell (iPSC)-derived immune cell types for the utility in CAR-T and other cell therapies.

    • Hospitals and Health Care
    • 700 & Above Employee
    • Postdoctoral Research Fellow
      • Jun 2019 - Sep 2019

    • Graduate Student
      • Jul 2013 - Jun 2019

      My predoctoral research was centered on innate immune signaling genes in Myelodysplastic Syndrome. I believe the findings from my research will contribute greatly to the scientific community, as they will provide mechanistic insight into the progression and pathogenesis of hematologic malignancies. These contributions will hopefully impact the development of new treatment strategies for the growing number of patients at risk for the disease.

    • Higher Education
    • 700 & Above Employee
    • Undergraduate Research Assistant
      • Jan 2011 - May 2013

      Investigating the mechanism underlying the improved outcomes of patients with Human Papillomavirus (HPV)-associated head and neck cancer compared to alcohol and tobacco related head and neck cancer In the Harari Lab under the guidance of Dr. Randall Kimple, I studied the differences in the sensitivity of HPV+ and HPV- cells to ionizing radiation, a common component of treatment for patients with head and neck cancer. I learned several foundational techniques including sterile technique,… Show more Investigating the mechanism underlying the improved outcomes of patients with Human Papillomavirus (HPV)-associated head and neck cancer compared to alcohol and tobacco related head and neck cancer In the Harari Lab under the guidance of Dr. Randall Kimple, I studied the differences in the sensitivity of HPV+ and HPV- cells to ionizing radiation, a common component of treatment for patients with head and neck cancer. I learned several foundational techniques including sterile technique, cell culture and maintenance of stable cell lines, and flow cytometry to assess the cell cycle distribution. As Dr. Kimple transitioned to an assistant professor, I continued to conduct research under his guidance investigating the clinical aspects of the response to radiation and chemotherapy using a mouse model. Mice received treatment of radiation, chemotherapy, or combination therapy and I measured tumors twice a week for six months where I practiced mouse handling and restraint. I learned several techniques to investigate the apoptotic properties and molecular pathways of HPV+ cells. Show less Investigating the mechanism underlying the improved outcomes of patients with Human Papillomavirus (HPV)-associated head and neck cancer compared to alcohol and tobacco related head and neck cancer In the Harari Lab under the guidance of Dr. Randall Kimple, I studied the differences in the sensitivity of HPV+ and HPV- cells to ionizing radiation, a common component of treatment for patients with head and neck cancer. I learned several foundational techniques including sterile technique,… Show more Investigating the mechanism underlying the improved outcomes of patients with Human Papillomavirus (HPV)-associated head and neck cancer compared to alcohol and tobacco related head and neck cancer In the Harari Lab under the guidance of Dr. Randall Kimple, I studied the differences in the sensitivity of HPV+ and HPV- cells to ionizing radiation, a common component of treatment for patients with head and neck cancer. I learned several foundational techniques including sterile technique, cell culture and maintenance of stable cell lines, and flow cytometry to assess the cell cycle distribution. As Dr. Kimple transitioned to an assistant professor, I continued to conduct research under his guidance investigating the clinical aspects of the response to radiation and chemotherapy using a mouse model. Mice received treatment of radiation, chemotherapy, or combination therapy and I measured tumors twice a week for six months where I practiced mouse handling and restraint. I learned several techniques to investigate the apoptotic properties and molecular pathways of HPV+ cells. Show less

  • Waisman Center
    • Madison, Wisconsin
    • Undergraduate Research Assistant
      • Nov 2010 - May 2013

      Induced Pluripotent Stem Cell technology to model Best Disease Dr. David Gamm’s Lab at the University of Wisconsin-Madison has developed a patient specific model to examine the cellular and molecular processes underlying a rare retinal degenerative disease known as Best Disease. The lab obtained skin cells from affected and unaffected members of the family that have a genetic defect in the Bestrophin 1 gene that causes this disease. These skin samples were transformed into stem cells… Show more Induced Pluripotent Stem Cell technology to model Best Disease Dr. David Gamm’s Lab at the University of Wisconsin-Madison has developed a patient specific model to examine the cellular and molecular processes underlying a rare retinal degenerative disease known as Best Disease. The lab obtained skin cells from affected and unaffected members of the family that have a genetic defect in the Bestrophin 1 gene that causes this disease. These skin samples were transformed into stem cells, and then into retinal pigment epithelium, the cells that are affected by this disease. During my time in his lab, I validated that the human induced pluripotent stem cell model system recapitulated clinical features of the disease. Furthermore, using the validated model system, I investigated the mechanisms contributing to the pathophysiology of Best Disease. Show less Induced Pluripotent Stem Cell technology to model Best Disease Dr. David Gamm’s Lab at the University of Wisconsin-Madison has developed a patient specific model to examine the cellular and molecular processes underlying a rare retinal degenerative disease known as Best Disease. The lab obtained skin cells from affected and unaffected members of the family that have a genetic defect in the Bestrophin 1 gene that causes this disease. These skin samples were transformed into stem cells… Show more Induced Pluripotent Stem Cell technology to model Best Disease Dr. David Gamm’s Lab at the University of Wisconsin-Madison has developed a patient specific model to examine the cellular and molecular processes underlying a rare retinal degenerative disease known as Best Disease. The lab obtained skin cells from affected and unaffected members of the family that have a genetic defect in the Bestrophin 1 gene that causes this disease. These skin samples were transformed into stem cells, and then into retinal pigment epithelium, the cells that are affected by this disease. During my time in his lab, I validated that the human induced pluripotent stem cell model system recapitulated clinical features of the disease. Furthermore, using the validated model system, I investigated the mechanisms contributing to the pathophysiology of Best Disease. Show less

Education

  • University of Cincinnati
    Doctor of Philosophy - PhD, Cancer and Cell Biology
    2013 - 2019
  • University of Wisconsin-Madison
    Bachelor's degree, Medical Microbiology and Immunology
    2009 - 2013

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