Sean Mack
Postdoctoral Fellow at Vaccine Production Program/NIAID/NIH- Claim this Profile
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English -
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Bio
Experience
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Vaccine Production Program/NIAID/NIH
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United States
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Biotechnology Research
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1 - 100 Employee
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Postdoctoral Fellow
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May 2021 - Present
• Contribute to the process development of CHO cell lines producing clinically relevant therapeutics • Leverage data analysis and metabolic modeling to predict optimal feeding strategies • Design and lead the execution of experiments with a 6-member team to ensure data relevancy and quality • Co-author standard operating procedure for Ambr250 operation • Mentor a post-baccalaureate fellow on experimental and computational techniques and professional development • Contribute to the process development of CHO cell lines producing clinically relevant therapeutics • Leverage data analysis and metabolic modeling to predict optimal feeding strategies • Design and lead the execution of experiments with a 6-member team to ensure data relevancy and quality • Co-author standard operating procedure for Ambr250 operation • Mentor a post-baccalaureate fellow on experimental and computational techniques and professional development
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University of Marlyand, College Park
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United States
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International Trade and Development
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1 - 100 Employee
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PhD Graduate Researcher, Chemical Engineering
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Aug 2014 - May 2020
Completed dissertation research under Dr. Daniel Dwyer and Dr. Ganesh Sriram • Identified the metabolic phenotypes of antibiotic resistant E. coli with and without antibiotic stress • Developed computational pipeline to integrate transcriptomics, metabolomics, and 13C isotope labeling data with a genome-scale metabolic model • Designed continuous growth experiments and collected multi-omics data (collaboration with Pacific Northwest National Laboratory) • Co-developed two… Show more Completed dissertation research under Dr. Daniel Dwyer and Dr. Ganesh Sriram • Identified the metabolic phenotypes of antibiotic resistant E. coli with and without antibiotic stress • Developed computational pipeline to integrate transcriptomics, metabolomics, and 13C isotope labeling data with a genome-scale metabolic model • Designed continuous growth experiments and collected multi-omics data (collaboration with Pacific Northwest National Laboratory) • Co-developed two computational tools, NetRed and NetFlow, that improve data analysis by reducing model complexity • Coordinated with external partners on joint projects, including responsibility and expectation setting, frequent communication, and review and provision of feedback on results Show less Completed dissertation research under Dr. Daniel Dwyer and Dr. Ganesh Sriram • Identified the metabolic phenotypes of antibiotic resistant E. coli with and without antibiotic stress • Developed computational pipeline to integrate transcriptomics, metabolomics, and 13C isotope labeling data with a genome-scale metabolic model • Designed continuous growth experiments and collected multi-omics data (collaboration with Pacific Northwest National Laboratory) • Co-developed two… Show more Completed dissertation research under Dr. Daniel Dwyer and Dr. Ganesh Sriram • Identified the metabolic phenotypes of antibiotic resistant E. coli with and without antibiotic stress • Developed computational pipeline to integrate transcriptomics, metabolomics, and 13C isotope labeling data with a genome-scale metabolic model • Designed continuous growth experiments and collected multi-omics data (collaboration with Pacific Northwest National Laboratory) • Co-developed two computational tools, NetRed and NetFlow, that improve data analysis by reducing model complexity • Coordinated with external partners on joint projects, including responsibility and expectation setting, frequent communication, and review and provision of feedback on results Show less
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Nemours
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United States
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Hospitals and Health Care
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700 & Above Employee
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Undergraduate Research Assistant
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Jan 2013 - May 2014
Completed senior thesis under Dr. Matthew Butchbach and Dr. Prasaad Dhurjati • Quantified impact of cAMP activators in spinal muscular atrophy fibroblasts using immunofluorescence • Developed a quantitative model of cAMP pathway to predict treatment mechanisms Completed senior thesis under Dr. Matthew Butchbach and Dr. Prasaad Dhurjati • Quantified impact of cAMP activators in spinal muscular atrophy fibroblasts using immunofluorescence • Developed a quantitative model of cAMP pathway to predict treatment mechanisms
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University of Delaware
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United States
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Higher Education
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700 & Above Employee
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Undergraduate Research Assistant
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Jan 2012 - Aug 2012
Conducted research under Dr. Millicent Sullivan • Formulated poly(Ethylene Glycol) conjugates for siRNA Delivery Conducted research under Dr. Millicent Sullivan • Formulated poly(Ethylene Glycol) conjugates for siRNA Delivery
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Innospec Fuel Specialties
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Chemical Manufacturing
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1 - 100 Employee
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Intern
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Jun 2011 - Feb 2012
Conducted quality control tests on customer fuel samples. Formulated new fuel additives to improve performance Conducted quality control tests on customer fuel samples. Formulated new fuel additives to improve performance
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Education
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University of Maryland College Park
Doctor of Philosophy - PhD, Chemical and Biomolecular Engineering -
University Of Delaware
Honors B.S. with Distinction, Chemical Engineering -
Don Bosco Prep
High School Diploma