Experience

MacroGenics, Inc.

• United States
• Biotechnology Research
• 200 - 300 Employee

• Director

  • Apr 2021 - Present

  Drug Product Sciences Drug Product Sciences



Pfizer

• United States
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Senior Principal Scientist/Group Leader

  • Oct 2019 - Apr 2021

• Principal Scientist/Group Leader

  • Oct 2016 - Sep 2019

• Principal Scientist

  • Jan 2012 - Sep 2016



Cook Pharmica

• United States
• Biotechnology Research
• 1 - 100 Employee

• Senior Scientist - Analytical & Formulation

  • Oct 2009 - Dec 2011

  • Analytical and formulation lead for various preclinical and clinical phase parenteral products in a CMO setting, delivering under aggressive timelines and managing multiple projects. • Developed and qualified analytical methods (SEC, cIEF, CE-SDS (r/nr), RP-HPLC) to support development and GMP stability. • Authored and reviewed technical reports and memos for the successful technology transfer to the cGMP manufacturing environment. • Coordinated with technical services and supervised… Show more • Analytical and formulation lead for various preclinical and clinical phase parenteral products in a CMO setting, delivering under aggressive timelines and managing multiple projects. • Developed and qualified analytical methods (SEC, cIEF, CE-SDS (r/nr), RP-HPLC) to support development and GMP stability. • Authored and reviewed technical reports and memos for the successful technology transfer to the cGMP manufacturing environment. • Coordinated with technical services and supervised manufacturing operations for GMP manufacturing campaigns. • Led higher order structure characterization, formulation development, compatibility studies, scale-down pilot studies, and freeze-dry cycle development. • Built new biophysical capabilities for analytical comparability and high-throughput formulation screening (DLS, DSC, DSF, CD, FT-IR, Fluorescence). • Represented CMO in business and scientific expositions and international conferences. Show less • Analytical and formulation lead for various preclinical and clinical phase parenteral products in a CMO setting, delivering under aggressive timelines and managing multiple projects. • Developed and qualified analytical methods (SEC, cIEF, CE-SDS (r/nr), RP-HPLC) to support development and GMP stability. • Authored and reviewed technical reports and memos for the successful technology transfer to the cGMP manufacturing environment. • Coordinated with technical services and supervised… Show more • Analytical and formulation lead for various preclinical and clinical phase parenteral products in a CMO setting, delivering under aggressive timelines and managing multiple projects. • Developed and qualified analytical methods (SEC, cIEF, CE-SDS (r/nr), RP-HPLC) to support development and GMP stability. • Authored and reviewed technical reports and memos for the successful technology transfer to the cGMP manufacturing environment. • Coordinated with technical services and supervised manufacturing operations for GMP manufacturing campaigns. • Led higher order structure characterization, formulation development, compatibility studies, scale-down pilot studies, and freeze-dry cycle development. • Built new biophysical capabilities for analytical comparability and high-throughput formulation screening (DLS, DSC, DSF, CD, FT-IR, Fluorescence). • Represented CMO in business and scientific expositions and international conferences. Show less



Ivy Tech Community College

• United States
• Higher Education
• 700 & Above Employee

• Adjunct Faculty in the Biotechnology Program

  • Jan 2010 - Jun 2011

  o Taught Protein Chemistry course for Associate degree students in the Biotechnology Program. o Taught Protein Chemistry course for Associate degree students in the Biotechnology Program.



Indiana University Bloomington

• United States
• Higher Education
• 700 & Above Employee

• Research Scientist

  • Oct 2004 - Jun 2009

  Research Scientist in the same lab at Texas A&M University between October 2004 and June 2007 Overarching Research Theme: Metal-induced allosteric switches in winged helix bacterial repressor proteins: A story of the evolution of allostery studied using high resolution protein NMR and biophysical tools • Supported in the design and functioning of a brand new biomolecular NMR facility (800 MHz/600 MHz with cyroprobes) in the Department of Chemistry, Indiana University… Show more Research Scientist in the same lab at Texas A&M University between October 2004 and June 2007 Overarching Research Theme: Metal-induced allosteric switches in winged helix bacterial repressor proteins: A story of the evolution of allostery studied using high resolution protein NMR and biophysical tools • Supported in the design and functioning of a brand new biomolecular NMR facility (800 MHz/600 MHz with cyroprobes) in the Department of Chemistry, Indiana University • Developed and optimized TROSY based NMR experiments for assignment and structure determination of selectively methyl labeled CzrA in complex with a 28 bp operator DNA (a 42 kDa complex) using 800 and 900 MHz NMR data. • Utilized protein engineering and fluorescence anisotropy binding assays to validate the structural model for CzrA-DNA complex. • Characterized the role of entropic contributions (dynamics) to long-range coupling of allosteric binding sites in CzrA using NMR and ITC. • Collaborated with multi-disciplinary faculties. • Published 7 peer-reviewed articles (including articles in Proceedings of the National Academy of Sciences, Journal of Molecular Biology, JACS and Biochemistry) and presented in several international conferences and academic institutions. Show less Research Scientist in the same lab at Texas A&M University between October 2004 and June 2007 Overarching Research Theme: Metal-induced allosteric switches in winged helix bacterial repressor proteins: A story of the evolution of allostery studied using high resolution protein NMR and biophysical tools • Supported in the design and functioning of a brand new biomolecular NMR facility (800 MHz/600 MHz with cyroprobes) in the Department of Chemistry, Indiana University… Show more Research Scientist in the same lab at Texas A&M University between October 2004 and June 2007 Overarching Research Theme: Metal-induced allosteric switches in winged helix bacterial repressor proteins: A story of the evolution of allostery studied using high resolution protein NMR and biophysical tools • Supported in the design and functioning of a brand new biomolecular NMR facility (800 MHz/600 MHz with cyroprobes) in the Department of Chemistry, Indiana University • Developed and optimized TROSY based NMR experiments for assignment and structure determination of selectively methyl labeled CzrA in complex with a 28 bp operator DNA (a 42 kDa complex) using 800 and 900 MHz NMR data. • Utilized protein engineering and fluorescence anisotropy binding assays to validate the structural model for CzrA-DNA complex. • Characterized the role of entropic contributions (dynamics) to long-range coupling of allosteric binding sites in CzrA using NMR and ITC. • Collaborated with multi-disciplinary faculties. • Published 7 peer-reviewed articles (including articles in Proceedings of the National Academy of Sciences, Journal of Molecular Biology, JACS and Biochemistry) and presented in several international conferences and academic institutions. Show less



Vanderbilt University Medical Center

• United States
• Hospitals and Health Care
• 700 & Above Employee

• Postdoctoral Research Fellow

  • Apr 2000 - Aug 2004

  Overarching Research Theme: Molecular basis of Replication Protein A functions in DNA replication pathway: A structural, biochemical and biophysical perspective • Instrumental in designing a biophysical research lab in a multidisciplinary group. • Characterized and mapped protein-protein interactions of RPA and SV40 T antigen origin binding domain using affinity chromatography, fluorescence, ITC and NMR. • Designed point mutants on both proteins based on a model structure and… Show more Overarching Research Theme: Molecular basis of Replication Protein A functions in DNA replication pathway: A structural, biochemical and biophysical perspective • Instrumental in designing a biophysical research lab in a multidisciplinary group. • Characterized and mapped protein-protein interactions of RPA and SV40 T antigen origin binding domain using affinity chromatography, fluorescence, ITC and NMR. • Designed point mutants on both proteins based on a model structure and tested for its binding and activity using biophysical and enzyme/cell-based assays. • Screened and optimized crystallization conditions for the X-ray structure determination of SV40 T antigen in complex with double stranded origin DNA. • Published 6 peer-reviewed articles (including articles in Nature Structural & Molecular Biology, EMBO J, JBC, Protein Science) and presented in several international conferences and academic institutions. Show less Overarching Research Theme: Molecular basis of Replication Protein A functions in DNA replication pathway: A structural, biochemical and biophysical perspective • Instrumental in designing a biophysical research lab in a multidisciplinary group. • Characterized and mapped protein-protein interactions of RPA and SV40 T antigen origin binding domain using affinity chromatography, fluorescence, ITC and NMR. • Designed point mutants on both proteins based on a model structure and… Show more Overarching Research Theme: Molecular basis of Replication Protein A functions in DNA replication pathway: A structural, biochemical and biophysical perspective • Instrumental in designing a biophysical research lab in a multidisciplinary group. • Characterized and mapped protein-protein interactions of RPA and SV40 T antigen origin binding domain using affinity chromatography, fluorescence, ITC and NMR. • Designed point mutants on both proteins based on a model structure and tested for its binding and activity using biophysical and enzyme/cell-based assays. • Screened and optimized crystallization conditions for the X-ray structure determination of SV40 T antigen in complex with double stranded origin DNA. • Published 6 peer-reviewed articles (including articles in Nature Structural & Molecular Biology, EMBO J, JBC, Protein Science) and presented in several international conferences and academic institutions. Show less