Experience

BioAgilytix

• United States
• Biotechnology Research
• 700 & Above Employee

• Scientist III, DMPK at BioAgilytix

  • 2022 - Present



Metacrine, Inc.

• United States
• Biotechnology Research
• 1 - 100 Employee

• Scientist I, DMPK

  • 2020 - 2022

  • Organized and executed a targeted metabolomics assay, using the Biocrates MxP Quant500 kit with LC-MS/MS, in an effort to identify promising PD biomarkers • Developed robust, in-house LC-MS/MS methods to monitor biomarkers in PD studies • Organized and executed a targeted metabolomics assay, using the Biocrates MxP Quant500 kit with LC-MS/MS, in an effort to identify promising PD biomarkers • Developed robust, in-house LC-MS/MS methods to monitor biomarkers in PD studies



Ferring Pharmaceuticals

• Switzerland
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Sr. Research Associate II

  • 2006 - 2020

  • Represented the ADME and Bioanalytical department on several project teams, organizing project ADME and DMPK activities in-house and with CROs, and reporting timelines and generated data back to the project team • Provided dosing guidance to in vivo department members for early PD studies • Designed PK studies in various preclinical species, assigning the initial dose, dose vehicle, route of administration, and sampling times • Developed reproducible and rugged LC/MS/MS methods for… Show more • Represented the ADME and Bioanalytical department on several project teams, organizing project ADME and DMPK activities in-house and with CROs, and reporting timelines and generated data back to the project team • Provided dosing guidance to in vivo department members for early PD studies • Designed PK studies in various preclinical species, assigning the initial dose, dose vehicle, route of administration, and sampling times • Developed reproducible and rugged LC/MS/MS methods for the quantitative and qualitative analysis of peptides and small molecules in biological samples • Prepared biological samples from studies in various preclinical species using plasma precipitation, SPE, and IP • Calculated PK parameters using Excel templates, Phoenix WinNonlin, and Thermo Watson LIMS • Reviewed peer generated, quantitative LC/MS/MS data • Prepared research reports for the transfer of project information to early development team members • Prepared electronic notebook reports • Operated Sciex 4000, 5000, 5500, 6500 MS platforms coupled to Shimadzu UPLC systems using Analyst software, Thermo LCQ MS systems using Xcalibur, and Agilent HPLC and UPLCs using ChemStation and Lab Advisor • Experienced working with Hamilton Star liquid handling system • Trained in DMPK in vitro assays such as microsomal and hepatocyte stability, MDCK-hMDR1 permeability, and plasma protein binding using ultracentrifugation • Trained and managed the workload for several part-time colleagues responsible for weighing compounds and performing buffer stability, quality control via HPLC and MS, sample preparation by plasma precipitation, and quantitative PK analysis using LC/MS/MS

• Laboratory Assistant

  • 2004 - 2006

  • Conducted reverse phase HPLC and MS experiments to provide purity and mass ID on all experimental compounds • Performed buffer and plasma stability studies using HPLC • Maintained analytical data and compound storage information in the organization’s compound database • Weighed and dispensed compounds for all experiments performed in-house and with CROs • Organized paperwork and packaging for shipping compounds off-site