Adam Hartman
Senior Research Engineer at Acorda Therapeutics, Inc.- Claim this Profile
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Bio
Experience
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Acorda Therapeutics, Inc.
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United States
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Biotechnology Research
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100 - 200 Employee
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Senior Research Engineer
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Feb 2020 - Present
Waltham, Massachusetts, United States • Tasked to scale up current commercial process to a size seven pharmaceutical spray dryer (PSD-7) • Designed a study that will be used to generate points for a design of experiments (DOE) on the PSD-7
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Research Engineer
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Jun 2018 - Jan 2020
Waltham, Massachusetts, United States • Developed and optimized mRNA powder with suitable aerosol and physical properties to be delivered via inhalation • Characterized powder using thermal gravimetric analysis, differential scanning calorimetry, x-ray powder diffraction, geometric particle size distribution, and aerosol particle size distribution • Lead author on pending patent for work on the mRNA powder • Set up a PSD-1 for use in research and development • Tasked to scale up current commercial process to a PSD-5… Show more • Developed and optimized mRNA powder with suitable aerosol and physical properties to be delivered via inhalation • Characterized powder using thermal gravimetric analysis, differential scanning calorimetry, x-ray powder diffraction, geometric particle size distribution, and aerosol particle size distribution • Lead author on pending patent for work on the mRNA powder • Set up a PSD-1 for use in research and development • Tasked to scale up current commercial process to a PSD-5 operated by a CMO • Performed a hazard and operability study and a failure mode and effects analysis for the PSD-5 • Designed and ran a DOE on the PSD-5 in order to generate a proven acceptable range for the PSD-5 • Helped design a DOE for a new packaging line
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Concert Pharmaceuticals, Inc.
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United States
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Pharmaceutical Manufacturing
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1 - 100 Employee
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Pharmaceutical Development Co-op
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Jul 2017 - Dec 2017
Lexington, Ma • Performed solubility testing to determine the optimal solvent composition for a crystallization pathway • Designed a distillative and temperature dependent crystallization pathway to increase the yield and purity of the active pharmaceutical ingredient (API) • Characterized the crystallized API for purity and yield using thermal gravimetric analysis, differential scanning calorimetry, liquid chromatography, quantitative NMR, microscopy, and x-ray powder diffraction • Tested… Show more • Performed solubility testing to determine the optimal solvent composition for a crystallization pathway • Designed a distillative and temperature dependent crystallization pathway to increase the yield and purity of the active pharmaceutical ingredient (API) • Characterized the crystallized API for purity and yield using thermal gravimetric analysis, differential scanning calorimetry, liquid chromatography, quantitative NMR, microscopy, and x-ray powder diffraction • Tested different chemical pathways to synthesize a new API Show less
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Nuvera Fuel Cells, LLC
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United States
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Engines and Power Transmission Equipment Manufacturing
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100 - 200 Employee
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Electrochemical Co-op
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Jul 2016 - Dec 2016
Billerica, Ma • Analyzed field data to discover the source of widespread system failures in a fuel cell engine, PowerEdge, and took part in meetings to determine solutions for the error • Tested a new orifice for the PowerEdge system to resolve system failures • Performed quality control on PowerEdge systems and resolved build errors when they appeared • Tested new software builds for the PowerEdge system
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Formulation Co-op
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Jun 2015 - Dec 2015
Watertown, Ma • Synthesized polymeric synthetic vaccine nanoparticles (SVPs) by sonication, high pressure homogenization, and nanoprecipitation • Designed formulations for SVPs to create second generation tolerogenic nanoparticles • Characterized SVPs by size and gravimetric yield • Prepared animal studies to test the efficacy of SVPs in mice and non-human primates
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Tutor
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Sep 2014 - Jun 2015
Boston, Ma • Review material for upcoming tests, review concepts students are having trouble understanding, work through assigned homework problems • Requires having received an A or A- in the course • Learning to skillfully communicate concepts and important information to students
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Education
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Northeastern University
Bachelor of Science (BS), Chemical Engineering -
Ashland High School
High School Diploma