Adam Hartman

Senior Research Engineer at Acorda Therapeutics, Inc.
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Contact Information
us****@****om
(386) 825-5501
Location
Medford, Massachusetts, United States, US

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Experience

    • United States
    • Biotechnology Research
    • 100 - 200 Employee
    • Senior Research Engineer
      • Feb 2020 - Present

      Waltham, Massachusetts, United States • Tasked to scale up current commercial process to a size seven pharmaceutical spray dryer (PSD-7) • Designed a study that will be used to generate points for a design of experiments (DOE) on the PSD-7

    • Research Engineer
      • Jun 2018 - Jan 2020

      Waltham, Massachusetts, United States • Developed and optimized mRNA powder with suitable aerosol and physical properties to be delivered via inhalation • Characterized powder using thermal gravimetric analysis, differential scanning calorimetry, x-ray powder diffraction, geometric particle size distribution, and aerosol particle size distribution • Lead author on pending patent for work on the mRNA powder • Set up a PSD-1 for use in research and development • Tasked to scale up current commercial process to a PSD-5… Show more • Developed and optimized mRNA powder with suitable aerosol and physical properties to be delivered via inhalation • Characterized powder using thermal gravimetric analysis, differential scanning calorimetry, x-ray powder diffraction, geometric particle size distribution, and aerosol particle size distribution • Lead author on pending patent for work on the mRNA powder • Set up a PSD-1 for use in research and development • Tasked to scale up current commercial process to a PSD-5 operated by a CMO • Performed a hazard and operability study and a failure mode and effects analysis for the PSD-5 • Designed and ran a DOE on the PSD-5 in order to generate a proven acceptable range for the PSD-5 • Helped design a DOE for a new packaging line

    • United States
    • Pharmaceutical Manufacturing
    • 1 - 100 Employee
    • Pharmaceutical Development Co-op
      • Jul 2017 - Dec 2017

      Lexington, Ma • Performed solubility testing to determine the optimal solvent composition for a crystallization pathway • Designed a distillative and temperature dependent crystallization pathway to increase the yield and purity of the active pharmaceutical ingredient (API) • Characterized the crystallized API for purity and yield using thermal gravimetric analysis, differential scanning calorimetry, liquid chromatography, quantitative NMR, microscopy, and x-ray powder diffraction • Tested… Show more • Performed solubility testing to determine the optimal solvent composition for a crystallization pathway • Designed a distillative and temperature dependent crystallization pathway to increase the yield and purity of the active pharmaceutical ingredient (API) • Characterized the crystallized API for purity and yield using thermal gravimetric analysis, differential scanning calorimetry, liquid chromatography, quantitative NMR, microscopy, and x-ray powder diffraction • Tested different chemical pathways to synthesize a new API Show less

    • United States
    • Engines and Power Transmission Equipment Manufacturing
    • 100 - 200 Employee
    • Electrochemical Co-op
      • Jul 2016 - Dec 2016

      Billerica, Ma • Analyzed field data to discover the source of widespread system failures in a fuel cell engine, PowerEdge, and took part in meetings to determine solutions for the error • Tested a new orifice for the PowerEdge system to resolve system failures • Performed quality control on PowerEdge systems and resolved build errors when they appeared • Tested new software builds for the PowerEdge system

    • Formulation Co-op
      • Jun 2015 - Dec 2015

      Watertown, Ma • Synthesized polymeric synthetic vaccine nanoparticles (SVPs) by sonication, high pressure homogenization, and nanoprecipitation • Designed formulations for SVPs to create second generation tolerogenic nanoparticles • Characterized SVPs by size and gravimetric yield • Prepared animal studies to test the efficacy of SVPs in mice and non-human primates

    • Tutor
      • Sep 2014 - Jun 2015

      Boston, Ma • Review material for upcoming tests, review concepts students are having trouble understanding, work through assigned homework problems • Requires having received an A or A- in the course • Learning to skillfully communicate concepts and important information to students

Education

  • Northeastern University
    Bachelor of Science (BS), Chemical Engineering
    2013 - 2018
  • Ashland High School
    High School Diploma
    2009 - 2013

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