Wenchen Zhao

at Genevant Sciences
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Contact Information
us****@****om
(386) 825-5501
Location
Vancouver, British Columbia, Canada, CA

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Experience

    • Canada
    • Biotechnology
    • 1 - 100 Employee
      • Apr 2023 - Present

      • Feb 2022 - Apr 2023

    • Canada
    • Biotechnology Research
    • 100 - 200 Employee
    • Research Associate, Preclinical
      • Jul 2019 - Jan 2022

      - Prepared formulations such as liposomes, lipid nanoparticles, polymeric nanoparticles for small molecules, peptides, viruses, and nucleic acid delivery using microfluidic mixing technology - Conducted downstream processing to buffer exchange formulations into desired buffer condition - Optimized formulation parameters and downstream processing such as tangential flow filtration to scale up formulation and reduce operation time - Performed formulation characterization and in vitro assays to determine the physicochemical, biological properties of nanoparticle formulations - Communicated with client of diverse backgrounds to discuss experimental results and coordinate study execution and in vivo/in vitro potency studies - Prepared Standard Operating Procedures (SOPs), study reports and technical presentations - Completed >10 formulation development projects from early-stage proof-of-concept formulations to manufacturing process scale-up for preclinical/clinical testing Show less

    • Canada
    • Higher Education
    • 700 & Above Employee
    • Research Assistant (Tech 3), Wellington Lab
      • Oct 2018 - Jul 2019

      - Examined drug activities of apoE modulators in iPSC-derived human astrocytes (isogenic E3/E3 vs. E4/E4) and primary murine mixed glia derived from wild-type and apoE2, apoE3, and apoE4 targeted-replacement mice - Examined drug activities of apoE modulators in iPSC-derived human astrocytes (isogenic E3/E3 vs. E4/E4) and primary murine mixed glia derived from wild-type and apoE2, apoE3, and apoE4 targeted-replacement mice

    • Canada
    • Education Administration Programs
    • 1 - 100 Employee
    • Self-study supervisor (0.2 FTE)
      • Apr 2019 - Jun 2019

      - Supervised high school students to complete homework and report to company regarding individual’s study progression - Answered academic questions and teach various high school subjects - Supervised high school students to complete homework and report to company regarding individual’s study progression - Answered academic questions and teach various high school subjects

    • Canada
    • Higher Education
    • 700 & Above Employee
      • May 2015 - Aug 2016

      - Performed various in vitro assays evaluating activity of several therapeutic drugs in terms of modulating apolipoprotein E levels in human and mouse astrocytes- Conducted drug target validation and studied mechanisms of action (MOA) of several apoE modulators- Played significant role in experimental planning, reported regularly to external collaborator via teleconference and collected feedback

      • Jan 2015 - Apr 2015

      - Extracted bone marrow contents from mice and selected B lymphocytes population using magnetic separation - Stimulated B cell differentiation by IL-7 treatment and monitored differentiation status using Flow Cytometry- Conducted in vitro PCR assay to examine the V(D)J rearrangement status of B cells

      • May 2014 - Dec 2014

      - Assembled novel plasmid constructs containing four essential T7 bacteriophage enzymes required for its DNA replication/transcription machinery- Site-directed mutagenized construct containing point mutation in order to express target protein of interest- Helped recruit new team members for 2015 iGEM competition and delivered info session regarding the content of competition as well as the application process

    • Canada
    • Higher Education
    • 700 & Above Employee
    • Undergraduate Research Assistant
      • May 2013 - Aug 2013

      - Utilized various bioinformatics tools including Blast2Go, Ingenuity Pathways Analysis (IPA), STRING Database to study the plasma protein profiles of mice infected by various Plasmodium parasites - Conducted Western Blot analysis to verify the quantities of certain proteins of interest determined by LC-MS/MS - Utilized various bioinformatics tools including Blast2Go, Ingenuity Pathways Analysis (IPA), STRING Database to study the plasma protein profiles of mice infected by various Plasmodium parasites - Conducted Western Blot analysis to verify the quantities of certain proteins of interest determined by LC-MS/MS

Education

  • The University of British Columbia
    Master's degree, Pathology and Laboratory Medicine
    2016 - 2018
  • The University of British Columbia
    Bachelor's degree, Honours in Biotechnology
    2011 - 2016
  • British Columbia Institute of Technology
    Diploma of Technology, Honours in Biotechnology
    2012 - 2014

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