Experience

National Center for Advancing Translational Sciences (NCATS)

• United States
• Research
• 200 - 300 Employee

• Staff Scientist

  • Jul 2023 - Present

  Rockville, Maryland, United States Lead of Metabolite Identification and Cell Permeability/Efflux transporters assays for optimization of drugs in discovery and development stages.

• Research Fellow

  • Jan 2021 - Jul 2023

  Rockville, Maryland, United States

• Postdoctoral Fellow

  • Jan 2018 - Jan 2021

  Baltimore, Maryland Area Automating the Metabolite Identification for the DMPK group at NCATS from incubation to analysis. Build a metabolite database for small molecules. Push forward laboratory capability from microsome fractions to cell systems (hepatocyte, organ-in-chip). Push forward laboratory capabilities for permeability studies from PAMPA to 96-well Caco-2 permeability/transporters study for Tier II studies of lead comounds.

• Pre Doctoral Fellow

  • Jun 2017 - Jan 2018

  Baltimore, Maryland Area Training in Metabolite Identification of compounds for the treatment of Fibrodysplasia Ossificans Progressiva. The metabolite identification was performed by incubating a series of compounds with liver microsomes from human and mouse. Samples were analyzed with UPLC/QTOF system operating in the MSe mode(Synapt G2-Si). Data analyzed were performed with Metabolynx software. The collaboration was made possible by the BEPE program with Sao Paulo Research Foundation (FAPESP).



Universidade Estadual Paulista Júlio de Mesquita Filho

• Brazil
• Higher Education
• 700 & Above Employee

• PHD Degree

  • Feb 2014 - Oct 2017

  São Carlos e Região, Brasil Thesis: PHARMACOKINETIC SCREENING AND IN VITRO STUDIES FOR THE SELECTION OF THIAZOLIDINODIONS PROMISING ORAL ADMINISTRATION It comprised the evaluation of the characteristics of new molecules for the treatment of type 2 diabetes / atherosclerosis: GQ-02, GQ-19, GQ-11 and GQ-177 synthesized by the Federal University of Pernambuco. For this, it was necessary to validate analytical and bioanalytical methods by UPLC / UV, use of techniques for the evaluation of solubility at different pHs, log P… Show more Thesis: PHARMACOKINETIC SCREENING AND IN VITRO STUDIES FOR THE SELECTION OF THIAZOLIDINODIONS PROMISING ORAL ADMINISTRATION It comprised the evaluation of the characteristics of new molecules for the treatment of type 2 diabetes / atherosclerosis: GQ-02, GQ-19, GQ-11 and GQ-177 synthesized by the Federal University of Pernambuco. For this, it was necessary to validate analytical and bioanalytical methods by UPLC / UV, use of techniques for the evaluation of solubility at different pHs, log P evaluation by chromatographic method, permeability of molecules in Caco-2 monolayers and administration of oral and intravenous drug in Wistar rats.

• Masters Degree

  • Mar 2012 - Feb 2014

  Araraquara/Sao Paulo/Brazil Validation of the pre-clinical bioanalytical and pharmacokinetic method for the new compound Lyso-07 in Wistar rats with UPLC/UV analysis. Collaboration in several projects in the laboratory. Trainee training until they are self-sufficient to take responsibility for a scientific initiation project. Achievements so far have been in the selection and acquisition of competent Scientific Initiation students. The mentioned project was contemplated with of FAPESP award.

• Scientific Undergraduate Training - Pharmacy and Biochemistry - FAPESP award

  • Mar 2011 - Dec 2012

  Araraquara/Sao Paulo/Brazil FAPESP Awarded Project - Treatment of Tuberculosis: a study of pharmacokinetic interactions of isoniazid. participation in the IV Brazilian Congress of Toxicology, 2012, Águas de Lindóia. Annals of the IV Brazilian Congress of Clinical Toxicology, 2012. Publication of the article "Pharmacokinetic and safety evaluation of the use of cyprofloxacin on an isoniazid-rifampicin regimen in rabbits" DOI: 10.1002 / bdd.1817



School of Pharmaceutical Sciences UNESP - Department of Natural Active Principles and Toxicology

• Student/Training

  • Oct 2007 - Feb 2010

  Araraquara, Sao Paulo, Brasil Learning in diverse equipments and handling of animals. Development of bioanalytical methods for quantitation of isoniazid in plasma by HPLC/UV