Experience

Reata Pharmaceuticals, Inc.

• United States
• Pharmaceutical Manufacturing
• 200 - 300 Employee

• Principal Scientist Computational Chemistry

  • Jan 2023 - Present

  My current role at Reata Pharmaceuticals Inc has two major directions: • Understanding the mechanism of action (MOA) of compounds with known efficacy at molecular interaction level. • Collaborating with medicinal chemists for designing new compounds.

• Senior Scientist Computational Chemistry

  • Jun 2021 - Jan 2023

• Postdoctoral Fellow Computational Chemistry

  • Aug 2020 - May 2021



UNT Health Science Center

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral Research Associate

  • Feb 2017 - Jul 2020

  I worked in the Liu lab (https://www.unthsc.edu/college-of-pharmacy/research-and-innovation/jin-liu-lab/) in the department of Pharmaceutical Sciences in the University of North Texas, Health Science Center as a postdoctoral research associate. My experience as postdoc includes: • Development of a method for studying protein allostery with combination of Machine Learning and Molecular Dynamics that generates Residue Response Maps to define allosteric effects. • Explaining factors… Show more I worked in the Liu lab (https://www.unthsc.edu/college-of-pharmacy/research-and-innovation/jin-liu-lab/) in the department of Pharmaceutical Sciences in the University of North Texas, Health Science Center as a postdoctoral research associate. My experience as postdoc includes: • Development of a method for studying protein allostery with combination of Machine Learning and Molecular Dynamics that generates Residue Response Maps to define allosteric effects. • Explaining factors that affect affinity in bitopic dopamine receptor binding ligands, using docking and Molecular Dynamics and investigated the subtype selectivity in dopamine receptors. • Elucidating factors that cause ligand selectivity in dopamine receptor subtypes D2 and D3. • Discovering conformational bias in bitopic ligands for dopamine receptors and proposed an MD-based technique for filtering out low affinity ligands that bind to dopamine receptors. • Analyzing and proposing genes responsible for racial disparity against African American women with Triple Negative Breast Cancer (TNBC), using data analysis and machine learning techniques. • Collaborating with several experimental research groups and other teammates in the form of offering computational solutions for their research problems and performing computational modeling. Example projects were designing novel ligands for NGLY1, describing ligand interactions with HDAC8, GABA-A and TRL4 proteins, elucidating mechanism for CRISPR Cas 9. • Training over 10 MD, PharmD, high school, psychology and engineering students in short internship opportunities for computational biology and chemistry research in University of North Texas, Health Science Center. Show less I worked in the Liu lab (https://www.unthsc.edu/college-of-pharmacy/research-and-innovation/jin-liu-lab/) in the department of Pharmaceutical Sciences in the University of North Texas, Health Science Center as a postdoctoral research associate. My experience as postdoc includes: • Development of a method for studying protein allostery with combination of Machine Learning and Molecular Dynamics that generates Residue Response Maps to define allosteric effects. • Explaining factors… Show more I worked in the Liu lab (https://www.unthsc.edu/college-of-pharmacy/research-and-innovation/jin-liu-lab/) in the department of Pharmaceutical Sciences in the University of North Texas, Health Science Center as a postdoctoral research associate. My experience as postdoc includes: • Development of a method for studying protein allostery with combination of Machine Learning and Molecular Dynamics that generates Residue Response Maps to define allosteric effects. • Explaining factors that affect affinity in bitopic dopamine receptor binding ligands, using docking and Molecular Dynamics and investigated the subtype selectivity in dopamine receptors. • Elucidating factors that cause ligand selectivity in dopamine receptor subtypes D2 and D3. • Discovering conformational bias in bitopic ligands for dopamine receptors and proposed an MD-based technique for filtering out low affinity ligands that bind to dopamine receptors. • Analyzing and proposing genes responsible for racial disparity against African American women with Triple Negative Breast Cancer (TNBC), using data analysis and machine learning techniques. • Collaborating with several experimental research groups and other teammates in the form of offering computational solutions for their research problems and performing computational modeling. Example projects were designing novel ligands for NGLY1, describing ligand interactions with HDAC8, GABA-A and TRL4 proteins, elucidating mechanism for CRISPR Cas 9. • Training over 10 MD, PharmD, high school, psychology and engineering students in short internship opportunities for computational biology and chemistry research in University of North Texas, Health Science Center. Show less



University of Utah - Employment

• United States
• Higher Education
• 700 & Above Employee

• Research Assistant

  • Jan 2011 - Jan 2017

  I worked in the Cheatham lab at the University of Utah, which is a pioneer lab in nucleic acid modeling in the world as a research assistant during my PhD. My experience there includes: • Description the ion binding preference in a buried ion binding site in GAC (GTPase Associating Center) RNA via Thermodynamic Integration, Umbrella Sampling and unbiased Molecular Dynamics. • Elucidation of a key ion-dependent step in unfolding pathway of GAC (GTPase Associating Center) RNA via… Show more I worked in the Cheatham lab at the University of Utah, which is a pioneer lab in nucleic acid modeling in the world as a research assistant during my PhD. My experience there includes: • Description the ion binding preference in a buried ion binding site in GAC (GTPase Associating Center) RNA via Thermodynamic Integration, Umbrella Sampling and unbiased Molecular Dynamics. • Elucidation of a key ion-dependent step in unfolding pathway of GAC (GTPase Associating Center) RNA via Umbrella Sampling. • Description and analysis of various conformations generated for RNA dinucleotides by different RNA force fields and water models in fully converged ensembles generated by Temperature Replica Exchange Molecular Dynamics (TREMD) and unbiased Molecular Dynamics. • Identification of the unstabilizing effect of the crystallographic magnesium ions for ligand binding to IRES RNA of HCV via Docking and Molecular Dynamics. • Identification of the most accurate ligand partial atomic charge types for Docking highly charged benzimidazole ligands in IRES RNA of HCV using. • Identification of a second binding site for HCV IRES benzimidazole binders using via Docking and Molecular Dynamics using. Show less I worked in the Cheatham lab at the University of Utah, which is a pioneer lab in nucleic acid modeling in the world as a research assistant during my PhD. My experience there includes: • Description the ion binding preference in a buried ion binding site in GAC (GTPase Associating Center) RNA via Thermodynamic Integration, Umbrella Sampling and unbiased Molecular Dynamics. • Elucidation of a key ion-dependent step in unfolding pathway of GAC (GTPase Associating Center) RNA via… Show more I worked in the Cheatham lab at the University of Utah, which is a pioneer lab in nucleic acid modeling in the world as a research assistant during my PhD. My experience there includes: • Description the ion binding preference in a buried ion binding site in GAC (GTPase Associating Center) RNA via Thermodynamic Integration, Umbrella Sampling and unbiased Molecular Dynamics. • Elucidation of a key ion-dependent step in unfolding pathway of GAC (GTPase Associating Center) RNA via Umbrella Sampling. • Description and analysis of various conformations generated for RNA dinucleotides by different RNA force fields and water models in fully converged ensembles generated by Temperature Replica Exchange Molecular Dynamics (TREMD) and unbiased Molecular Dynamics. • Identification of the unstabilizing effect of the crystallographic magnesium ions for ligand binding to IRES RNA of HCV via Docking and Molecular Dynamics. • Identification of the most accurate ligand partial atomic charge types for Docking highly charged benzimidazole ligands in IRES RNA of HCV using. • Identification of a second binding site for HCV IRES benzimidazole binders using via Docking and Molecular Dynamics using. Show less



504 Hospital

• Tehran, Iran

• Hospital Management Secretary

  • Mar 2009 - Jan 2010

  Military service: Military service is obligatory for men in Iran. Hospital 504 was an army hospital in Iran in which I worked as the Management Secretary, a position which involved a lot of customer service and administrative tasks. Military service: Military service is obligatory for men in Iran. Hospital 504 was an army hospital in Iran in which I worked as the Management Secretary, a position which involved a lot of customer service and administrative tasks.



Gachsaran Petrochemical Co

• Tehran and Gachsaran, Iran

• Deputy of Health, Safety and Environment (HSE)

  • Jun 2004 - Jun 2007

  Part-time job during my masters: I worked as deputy of Health, Safety and Environment in Gachsaran petrochemical company, which was a plant located close to the city of Gachsaran in southwest of Iran. I was in the very first team who started the plan from scratch doing all kinds of initial administrative jobs; and later as the deputy of health, safety and environment until 2007. Part-time job during my masters: I worked as deputy of Health, Safety and Environment in Gachsaran petrochemical company, which was a plant located close to the city of Gachsaran in southwest of Iran. I was in the very first team who started the plan from scratch doing all kinds of initial administrative jobs; and later as the deputy of health, safety and environment until 2007.



Tarbiat Modares University

• Iran
• Higher Education
• 700 & Above Employee

• Research Assistant

  • Jan 2004 - Jul 2006

  Research Assistantship during my masters: I worked in Dr. Abdolmaleki's lab in the department of Biophysics of Tarbiat Modares University. My research involved characterization of small molecules and development of predictive ligand binding models using Artificial Neural Networks, Genetic Algorithms and Non-linear Regression Analysis. Research Assistantship during my masters: I worked in Dr. Abdolmaleki's lab in the department of Biophysics of Tarbiat Modares University. My research involved characterization of small molecules and development of predictive ligand binding models using Artificial Neural Networks, Genetic Algorithms and Non-linear Regression Analysis.



MD Company

• Tehran, Iran

• Foreign business communication staff

  • Jul 2001 - Sep 2002

  Off campus part-time job as a bachelor student: I worked as foreign business communication staff in an import/export company. Off campus part-time job as a bachelor student: I worked as foreign business communication staff in an import/export company.