Professor of Pharmaceutical Compounding

• Aug 2021 - Present

Pharmacist, Owner

• Jun 2018 - Present

Staff Pharmacist

• May 2017 - May 2018

Pharmacy Intern

• Oct 2013 - Apr 2017

Active role in the input, processing/billing, filling, verification, and patient counseling of all prescriptions. Active role in the input, processing/billing, filling, verification, and patient counseling of all prescriptions.

Staff Scientist/Principal Investigator - Department of Drug Metabolism

• Jul 2009 - Jul 2013

Performed metabolite identification and structure characterization using state of the art, high resolution, liquid chromatography mass spectrometry (LC-MS). Good laboratory practice (GLP) based metabolite profiling of test compounds utilizing high-performance liquid chromatography (HPLC) and radio-chromatography. Provided quantitative LC-MS support for pharmacokinetic/toxicokinetic (PK/TK) studies. Implementing and troubleshooting LC-MS instrumentation and method development. Performed metabolite identification and structure characterization using state of the art, high resolution, liquid chromatography mass spectrometry (LC-MS). Good laboratory practice (GLP) based metabolite profiling of test compounds utilizing high-performance liquid chromatography (HPLC) and radio-chromatography. Provided quantitative LC-MS support for pharmacokinetic/toxicokinetic (PK/TK) studies. Implementing and troubleshooting LC-MS instrumentation and method development.

Postdoctoral Research Fellow - Departments of Pharmacology & Toxicology and Pediatrics

• Sep 2006 - Jul 2009

Involved in projects comparing metabolism of inhaled glucocorticoids by cytochrome P450 3A enzymes in the lung (metabolite ID, structure elucidation (LC/MS), kinetic parameters (VMAX and KM)). Regulation of P450 3A enzymes in airway cells by inhaled glucocorticoids (qRT-PCR) and subsequent effects on glucocorticoid metabolism and developmental expression of P450 3A enzymes measuring P450 3A expression in airways of pediatric patients Performed preliminary work on a genotyping study (genotyping pediatric asthmatics for P450 3A polymorphisms). Show less

Research Assistant - Department of Biochemistry

• Jul 2003 - Aug 2006

Finding correlations between protein adduction with activation of specific cell signaling events (survival, death, apoptosis, etc.), more specifically activation of c-Jun N-terminal kinase, a member of the mitogen activated cell kinase (MAPK) family of enzymes and activation of apoptotic pathways. Also making chemical comparisons of extents of protein adduction in different cell types by different adducting agents (Michael vs. SN2 mechanism, etc.) Finding correlations between protein adduction with activation of specific cell signaling events (survival, death, apoptosis, etc.), more specifically activation of c-Jun N-terminal kinase, a member of the mitogen activated cell kinase (MAPK) family of enzymes and activation of apoptotic pathways. Also making chemical comparisons of extents of protein adduction in different cell types by different adducting agents (Michael vs. SN2 mechanism, etc.)

Graduate Student Researcher - Department of Pharmacology & Toxicology

• Jul 2001 - Jul 2003

Identifying protein adducts on glutathione S-transferase (GST) P1-1 using model Michael and SN2 mechanism based compounds by LC-MS techniques. Developed methodology to simultaneously compare multiple adduction sites on the same protein using N-terminal peptide labeling with phenyl isocyanate and quantitative LC-MS to calculate rate constant (k) for each site with different modifying chemicals. Identifying protein adducts on glutathione S-transferase (GST) P1-1 using model Michael and SN2 mechanism based compounds by LC-MS techniques. Developed methodology to simultaneously compare multiple adduction sites on the same protein using N-terminal peptide labeling with phenyl isocyanate and quantitative LC-MS to calculate rate constant (k) for each site with different modifying chemicals.