Alex (Drishti) Guin
Senior Bioinformatics Engineer at Rarebase- Claim this Profile
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Bio
Experience
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Rarebase
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United States
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Biotechnology
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1 - 100 Employee
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Senior Bioinformatics Engineer
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Jul 2023 - Present
Palo Alto, California, United States
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Bioinformatics Engineer
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May 2022 - Jul 2023
Palo Alto, California, United States
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UPSIDE Foods
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United States
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Food and Beverage Manufacturing
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200 - 300 Employee
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Computational Biologist
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Mar 2021 - May 2022
Berkeley, California, United States
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Synthego Corporation
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United States
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Biotechnology Research
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200 - 300 Employee
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Software Engineer - Data Scientist
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Jul 2020 - Mar 2021
Development of imaging analysis ETL for high-throughput analysis of bright-field, low-contrast and low-magnification images of cell plates. Image processing was written using Python's image processing toolkit (CV2 and Skimage) and data handling was built using Django. Designed algorithms to assess colony growth and cell health. Generated weekly reports on performance of pilot program for generation of clonal cell populations and led discussions on potential improvements and failure… Show more Development of imaging analysis ETL for high-throughput analysis of bright-field, low-contrast and low-magnification images of cell plates. Image processing was written using Python's image processing toolkit (CV2 and Skimage) and data handling was built using Django. Designed algorithms to assess colony growth and cell health. Generated weekly reports on performance of pilot program for generation of clonal cell populations and led discussions on potential improvements and failure points. Developed process metrics for the factory for generation of edited cell lines. Day-to-day data analysis of biological data including genomic sequencing data to support data needs of various teams across the company including process and factory operations including qualification of instrument and software workflows.
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Data Scientist
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Oct 2019 - Jul 2020
Menlo Park, California - Developed simulations to mimic factory performance and identification of possible failure modes. Generated recommendations based on simulation results to improve process efficiency (reduce failure rate) and reduce product turn around time. - Wrote instrument and software validation workflows. - Analysis and recommendation support for process and operations based on day-to-day data analysis.
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University of Illinois Urbana-Champaign
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United States
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Higher Education
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700 & Above Employee
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Graduate Research Assistant
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Aug 2013 - Jul 2019
Urbana-Champaign, Illinois Area • Analyzed fluorescence data from cells using image processing to study cellular processes in real-time. • Designed and built instrumentation and data collection pipeline to enhance data collection and cell-imaging for the laboratory research. • Conducted statistical analysis to derive population averages using non-linear regression from time-series data. • Mentored and trained two student interns in the summer, leading to 2 publications. • Formulated and wrote research grant with… Show more • Analyzed fluorescence data from cells using image processing to study cellular processes in real-time. • Designed and built instrumentation and data collection pipeline to enhance data collection and cell-imaging for the laboratory research. • Conducted statistical analysis to derive population averages using non-linear regression from time-series data. • Mentored and trained two student interns in the summer, leading to 2 publications. • Formulated and wrote research grant with supervisor for NSF (funded). Show less
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Insight Data Science
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United States
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Higher Education
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1 - 100 Employee
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Fellow, Health Data Science
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Jan 2019 - Jun 2019
San Francisco Bay Area • Developed a web-app to screen for Crohn’s disease and inflammatory bowel disease, using public microbiome sequencing data. • Performed feature selection and optimized SMOTE for oversampling and random forest for prediction to achieve a final recall score of 80%. • Built an app using Dash and Flask to implement above-mentioned tool.
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Indian Institute of Technology, Kharagpur
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India
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Higher Education
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700 & Above Employee
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Student
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Jul 2008 - Apr 2013
General Secretary, Office of Alumni Affairs and International Relations, 2010-11
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Technical University of Munich
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Germany
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Research Services
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700 & Above Employee
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Visiting Scholar
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May 2012 - Jul 2012
Munich Area, Germany Worked in the Department of Computational Biological Chemistry.
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Ruhr University Bochum
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Germany
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Research
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700 & Above Employee
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Visiting Scholar
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Nov 2011 - Jan 2012
Bochum Area, Germany Worked in the Department of Organic Chemistry.
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Massachusetts Institute of Technology
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United States
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Higher Education
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700 & Above Employee
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Visiting Scholar
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May 2011 - Jul 2011
Greater Boston Area Worked in the Department of Computational Chemistry.
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Karlsruhe Institute of Technology (KIT)
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Germany
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Higher Education
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700 & Above Employee
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Visiting Scholar
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Nov 2010 - Jan 2011
Karlsruhe Area, Germany Worked in the Department of Inorganic Chemistry.
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University of Illinois Urbana-Champaign
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United States
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Higher Education
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700 & Above Employee
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Visiting Scholar
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May 2010 - Jul 2010
Urbana-Champaign, Illinois Area Worked in the Department of Chemistry.
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Unilever
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United Kingdom
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Manufacturing
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700 & Above Employee
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Intern
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Nov 2009 - Dec 2009
Bengaluru Area, India Studies Micro-emulsions, properties and modelling through viscosity and conductivity studies.
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Pfizer
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United States
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Pharmaceutical Manufacturing
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700 & Above Employee
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Summer Intern
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Jun 2009 - Jul 2009
Mumbai Area, India Understanding Pharmaceutical production, management and quality control.
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Education
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University of Illinois at Urbana-Champaign
Doctor of Philosophy (PhD), Chemistry -
Indian Institute of Technology, Kharagpur
M.Sc, Chemistry