Experience

Orexia Therapeutics

• United Kingdom
• Biotechnology Research
• 1 - 100 Employee

• Head of Biology

  • Feb 2019 - Present



Jazz Pharmaceuticals

• Ireland
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Consultant, Neuropharmacology

  • Aug 2018 - Mar 2021



Reset Therapeutics

• Senior Principal Scientist

  • Apr 2016 - Mar 2018

  • Built and co-led in vivo biology department to support two drug discovery programs targeting circadian and hypocretin/orexin systems• Responsible for strategy, training, design, execution, analysis, reporting of efficacy studies in house and via CROs• Provided scientific leadership in neuroscience, liaison to KOL in sleep physiology, and represented in vivo department before scientific advisory board and external partners• Established innovative, rapid-screen, non-invasive assay for sleep/wake assessment• Sourced and validated rare mouse models of hypocretin/orexin neuron ablation • Implemented novel technology for real-time, multi-modal monitoring of vivarium environment to enable sleep and circadian research• Performed hands-on tissue sampling, dosing, and chronic survival surgery• Chair, IACUC• Orexin Program acquired by Alkermes; selected for technology transfer team



SRI

• United States
• Research Services
• 700 & Above Employee

• Research Scientist

  • Sep 2011 - Mar 2016

  Center for Neuroscience, Biosciences Division• Established preclinical narcolepsy therapeutics program with state-of-the-art models and cataplexy assay• Discovered component of repurposed drug improves murine narcolepsy symptoms better than first line medication• Pursued novel, non-monoaminergic targets as narcolepsy therapeutics for government and commercial clients as Principal Investigator• Mangaged 6 research associates and laboratory regulatory affairs

• Postdoctoral Fellow

  • Jan 2009 - Aug 2011

  Laboratory of Thomas Kilduff, Ph.D.• Investigated EEG-based biomarkers, circadian and arousal state dysfunction in mouse models of Huntington's and Parkinson's disease• Developed and implemented best practices for mouse colony management for 10x expansion in number of transgenic lines• Awarded Career Re-entry grant from National Institute of Neurological Disorders and Stroke to investigate therapeutic mechanism of action of gamma hydroxybutyrate for narcolepsy



self

• Independent Research/Education Professional

  • May 2001 - Dec 2008

  • Technical Writer/Editor for neuroscience publications• Director, Active Science Program, Palo Alto/Menlo Park Parents' Club• Director, Council Communications, ALSJCC T'enna Preschool• Web/Graphic Designer for education, e-commerce, publishing industries• Founded and managed volunteer childcare cooperative for 20+ families for 4 years • Technical Writer/Editor for neuroscience publications• Director, Active Science Program, Palo Alto/Menlo Park Parents' Club• Director, Council Communications, ALSJCC T'enna Preschool• Web/Graphic Designer for education, e-commerce, publishing industries• Founded and managed volunteer childcare cooperative for 20+ families for 4 years



Stanford University School of Medicine

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral Fellow

  • Mar 2000 - May 2001

  Laboratory of Emmanuel Mignot, M.D., Ph.D.• Awarded Dean’s Fellowship for investigation of hypocretin neuropharmacology in sleep• Conducted preclinical trials on hypocretin replacement therapy for treatment of narcolepsy• Expanded SCORE vigilance state monitoring technology at Stanford• Mentored undergraduate students• Collaborated on sleep-deprivation/gene expression studies

• Visiting Doctoral Researcher

  • Jul 1995 - Mar 2000

  Laboratory of Dale Edgar, Ph.D.• Conceived and executed nationally award-winning research in which the promotion of REM sleep tendency by the circadian pacemaker was discovered• Advanced real-time vigilance state monitoring technology through the development of an automated sleep-deprivation system for rodents (acquired by Eli Lilly)• Granted Individual NRSA from the NIMH• Selected as representative from the National Multi-Site Training Program in Basic Sleep Research from UCLA



University of Southern California

• United States
• Higher Education
• 700 & Above Employee

• Laboratory Technician

  • Jul 1992 - Jun 1993

  Laboratory of Sarah Bottjer, Ph.D.• Discovered novel circuitry and neurotopographical organization of the zebra finch song system• Supervised undergraduate research assistants & managed aviary Laboratory of Sarah Bottjer, Ph.D.• Discovered novel circuitry and neurotopographical organization of the zebra finch song system• Supervised undergraduate research assistants & managed aviary