Ramya T.N.C.
Senior Scientist at Institute Of Microbial Technology- Claim this Profile
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Bio
Experience
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Institute Of Microbial Technology
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Biotechnology
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100 - 200 Employee
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Senior Scientist
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Mar 2010 - Present
Current research interests The broad research interests of my group are in the area of glycobiology with specific emphasis on studying glycoconjugate-lectin interactions and carbohydrate-active enzymes. Past and ongoing research projects include - Understanding the role of ligand binding by the human intelectins in inflammation - Functional characterization of microbial proteins with F-type lectin domains - Host-commensal interactions mediated by microbial glycan-binding proteins under varied dietary conditions - Molecular characterization of flagellin glycosyltransferases - Recombinant expression of sialyltransferases for the synthesis of medically relevant oligosaccharides - Biochemical studies of microbial alginate lyases Research advisor of Ph.D. students. Current students (Akil Akhtar, Aasawari Khairnar and Sonal Mahajan); students awarded Ph.D. degree (Dr. Shailza Sharma, Dr. Ritika Bishnoi, Dr. Gurdeep Singh) Teach Pre-Ph.D. courses "Proteins" and "Data Analysis and Scientific Writing" 2012-2017: Nodal officer and Principal investigator of CSIR XII FYP project, “Man as a superorganism: Understanding the human microbiome” 2012-2015: Principal investigator of FAST-TRACK grant for project “Exploring the potential of F-type lectins to direct biological functions” from DST, Government of India 2012-2015: Principal investigator of CSIR-IMTECH research council approved project "Functional characterization of the human intelectins" Show less
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Research Associate
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Nov 2006 - Feb 2010
Research topics: Developing a method for efficient labeling of sialylated glycoproteins on living cells Mapping the B-cell glycoproteome Identifying trans counter-receptors of CD22 (Siglec-2) through a functional proteomics approach Other activities: Safety Officer in the Paulson laboratory from September 2007 to February 2010. Member, The Scripps Research Institute council of scientific editors, 2008-2010. Participated in communicating and popularizing science through the following reports. -http://www.scripps.edu/newsandviews/e_20080519/malaria.html -http://www.scripps.edu/newsandviews/e_20080421/onpress.html Mentored graduate student, Devin Sok on a lab rotation in the Paulson laboratory from August to November 2009. Research topic: Developing an approach to identify CD22-mediated heterotypic cell interactions. Mentored high school student, Connor Yates, during a summer internship in the Paulson laboratory from July to August 2009. Research topic: Developing cell surface glycoprotein labeling methods. Show less
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Indian Institute of Science
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India
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Research Services
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1 - 100 Employee
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Aug 2005 - Sep 2006
Research topic:Mechanism of action of 15-Deoxyspergualin on the malaria parasite, Plasmodium falciparum – effect on protein synthesis, polyamine synthesis and transport, and targeting of nucleus-encoded proteins to the apicoplast.
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Aug 2002 - Jul 2005
Research topics:Mechanism of anti-cancer action of 15- Deoxyspergualin – effect on Hsp70 and eukaryotic protein synthesis.
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Aug 2000 - Jul 2002
Research topics:Inhibitors of apicoplast functions in Plasmodium falciparum – “delayed death” vs “rapid death”.Biochemical studies on plant lectins.
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Education
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Indian Institute of Science
Ph.D., Molecular Biophysics -
University of Pune
Master's Degree, Biotechnology -
St. Francis College for Women, Begumpet, Hyderabad
Bachelor's Degree, Botany, Zoology, Chemistry -
St. Francis Junior College
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St. Michael's Academy