Experience

Morphic Therapeutic

• United States
• Pharmaceutical Manufacturing
• 1 - 100 Employee

• Scientist II

  • Jan 2023 - Present

  • Leading hit-finding campaigns against multiple exploratory targets for first-in-class SMi.• Managing CROs for DEL screenings, fragment screenings, hit validations, and protein productions.• Collaborating in cross-functional teams. Delivered biophysics assay results and 100+ proprietary structures for establishing SAR.• Developed LMW SPR methods for fragment screening, hit validation, and SMi characterization.• Investigated antibody MOA using ELISA, SPR, negative-stain EM, and protein crystallography.• Led application of AlphaFold2 in SAR analysis.• Engineered and produced proteins of interests for biochemical assays or protein crystallography. Show less

• Scientist I

  • Apr 2021 - Dec 2022



UC San Diego

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral Researcher

  • Jul 2019 - Apr 2021

  • Built a crystallography facility and delivered five biosynthetic enzyme structures under COVID restrictions. • Mentored three graduate students in protein biochemistry, structural biology, and enzyme mechanisms. • Built a crystallography facility and delivered five biosynthetic enzyme structures under COVID restrictions. • Mentored three graduate students in protein biochemistry, structural biology, and enzyme mechanisms.



Massachusetts Institute of Technology

• United States
• Higher Education
• 700 & Above Employee

• Graduate Research Assistant

  • Aug 2013 - May 2019

  • Solved and deposited 18 structures of oxygen-sensitive enzymes with substrates or inhibitors bound. • Designed and implemented biophysical assays to elucidate allosteric regulations of E. coli class Ia RNR. • Extensive experience in protein crystallography, from gene to structure. • Led and coordinated on-site and remote synchrotron data collections. • Mentored an undergraduate researcher in cloning, protein production, and structural biology. • Solved and deposited 18 structures of oxygen-sensitive enzymes with substrates or inhibitors bound. • Designed and implemented biophysical assays to elucidate allosteric regulations of E. coli class Ia RNR. • Extensive experience in protein crystallography, from gene to structure. • Led and coordinated on-site and remote synchrotron data collections. • Mentored an undergraduate researcher in cloning, protein production, and structural biology.



National Taiwan University

• Taiwan
• Higher Education
• 700 & Above Employee

• Research Assistant

  • May 2010 - Aug 2013

  • Integrated QM-MM and protein-protein docking to simulate light-harvesting kinetics. • Established skills in programming and algorithms. • Integrated QM-MM and protein-protein docking to simulate light-harvesting kinetics. • Established skills in programming and algorithms.