Experience

Swammerdam Institute for Life Sciences (SILS), University of Amsterdam

• Netherlands
• Research Services
• 1 - 100 Employee

• Assistant Professor

  • Jun 2022 - Present

  My lab focuses on unraveling parameters that influence epigenetic crosstalk at regulatory elements, how this relates to dynamic switching of transcriptional activity and how we can use this knowledge for targeted approaches involving epigenome editing. My lab focuses on unraveling parameters that influence epigenetic crosstalk at regulatory elements, how this relates to dynamic switching of transcriptional activity and how we can use this knowledge for targeted approaches involving epigenome editing.



Max Planck Institute for Molecular Genetics (MPI-MG)

• Germany
• Research Services
• 100 - 200 Employee

• Postdoctoral Researcher

  • 2016 - 2021

  Topic: Functional genomics of X chromosome inactivation during embryonic development •Systems biology approach to explore functional regulatory elements that regulate an essential developmental process in mouse embryonic stem cells •Implement technological innovations involving state of the art NGS technologies •Design, run and lead projects with several multidisciplinary collaborators •Project management, data acquisition, supervision of students, teaching Topic: Functional genomics of X chromosome inactivation during embryonic development •Systems biology approach to explore functional regulatory elements that regulate an essential developmental process in mouse embryonic stem cells •Implement technological innovations involving state of the art NGS technologies •Design, run and lead projects with several multidisciplinary collaborators •Project management, data acquisition, supervision of students, teaching



EpiGenie

• http://www.epigenie.com

• Schrijver

  • Jul 2014 - Jun 2017

  Writing feature articles about hot & new published scientific articles for a scientific audience with subjects ranging from; gene editing, epigenome editing, epigenetics. Writing feature articles about hot & new published scientific articles for a scientific audience with subjects ranging from; gene editing, epigenome editing, epigenetics.



UMCG

• Netherlands
• Hospitals and Health Care
• 700 & Above Employee

• Postdoctoral Researcher

  • Jan 2015 - Jul 2016

  Characterizing of a novel class of chromatin modifiers which interfere with cancer metastasis.In this project we are using: CRISPR-Cas9 system to generate KO's, ChIP-seq, RNA Micro-arrays and SILAC LC-MS proteomics approaches.

• PhD candidate

  • Jan 2011 - Dec 2014

  During my PhD project I studied the role of post-translational modifications of certain fibrosis and cancer related processes. Of particular interest was understanding the molecular functions and transcriptional (epigenetic) regulation of genes related to collagen deposition and cross-linking. Amongsts other things, I discovered novel interactions of enzymes that are important for the inititation of collagen cross-linking (PNAS). Also, I dissected the trancriptional regulation of collagen cross-linking gene PLOD2 in fibrotic fibroblasts (JBC). Furthermore, I used "state of the art" gene targeting tools (Zinc Fingers and CRISPR-dCas9) to initiate epigenetic editing as a manner to interfere with target gene expression (Nature Communications).This research was funded by the NIRM (Netherlands Institute for Regenerative Medicine), and in practice a collaboration of the labs of Prof. Dr. Ruud Bank (Tissue Generation & Repair group) and Prof. Dr. Marianne Rots (Epigenetic Editing group).My PhD was awarded with highest Dutch academic distinction.Click the link below to read my PhD thesis online. Show less