Experience

Lek Pharmaceuticals d.d.

• Slovenia
• Pharmaceutical Manufacturing
• 100 - 200 Employee

• Scientist Analytical Development - Chromatography

  • Jan 2019 - Present

• Scientist Analytical Development

  • Jul 2017 - Dec 2018



Max-Planck-Institut für Chemie

• Germany
• Research
• 1 - 100 Employee

• Research Scientist

  • Jul 2015 - Jun 2017

  • Development of a novel disk SPE procedure for extraction and preconcentration of nitro-aromatic compounds (nitrophenols, nitrocatechols, nitroguaiacols, nitrosalicylic acids) from snow and rainwater samples.• Transfer and optimization of an analytical method based on LC/MS (single quadrupole MSD equipped with an ESI source) for the analysis of nitro-aromatic compounds in atmospheric particulate matter and snow.• Sample preparation and LC/MS analysis of large sample sets collected during different sampling campaigns, as well as final data analysis and presentation.• Management of the workflow of a small analytical lab within the Multiphase Chemistry Department.



National Institute of Chemistry - Ljubljana, Slovenia

• Researcher

  • Jul 2013 - Jun 2015

  • Leading, planning, organizing and executing research activities of a post-doctoral project with pharmaceutical industry Lek Ljubljana - a Sandoz Company (Early-Career Researchers’ Grant)• Familiarization and implementation of pharmaceutical GMP during the course of my 3-month research work in Lek Ljubljana (as a part of my Early-Career Researchers’ Grant project)• Design, development, validation and application of original analytical methods based on RP, HILIC and chiral chromatography for analysis of novel active pharmaceutical ingredients and their degradation products.• Development of on-line derivatization – GC/FID and GC/MS methods for determination of tetracyclic and pentacyclic triterpenoids in epicuticular waxes from different vegetables.• Validation of a HPLC/UV impurity method for an active pharmaceutical ingredient (contract research for a pharmaceutical industry).

• Young researcher

  • Oct 2009 - Jun 2013

  • Development and validation of novel HILIC and RP methods based on liquid chromatography tandem mass spectrometry for determination of dicarboxylic acids and nitro-aromatic compounds in atmospheric aerosols, respectively.• Optimization of an ultrasound assisted solvent extraction method for extraction of dicarboxylic acids and nitro-aromatic compounds from quartz filters used for aerosol sampling.• Development and validation of specific HPLC/DAD methods for studying the heterogeneous ozonation of the pesticides trifluralin and isoproturon adsorbed on silica particles under atmospheric conditions (in collaboration with Dr. Maryline Pflieger, post-doctoral researcher).• Organization and execution of a bilateral research project with the Laboratory for Bioorganic Mass Spectrometry, Department of Pharmaceutical Sciences, University of Antwerp, Belgium (group of Prof. Dr. Magda Claeys).• Synthesis of methyl-nitrocatechol isomers and elucidation of product structure using 1H and 13C NMR, and 2D correlation spectroscopy (collaboration with the Slovenian NMR Center, National Institute of Chemistry, Ljubljana, Slovenia (principal scientist Dr. Alen Čusak)).• Investigation and evaluation of aerosol sample matrix effects on analyte ionization under ESI-MS.• Planning and execution of kinetic experiments on the aqueous-phase reactivity of guaiacol (2-methoxy-phenol) in presence of hydroxyl and nitro radicals.• Development of RP-SPE, analytical- and semi-preparative HPLC/DAD methods for isolation, fractionation and purification of guaiacol reaction products formed through aqueous-phase guaiacol photonitration.



Faculty of Pharmacy - Skopje

• North Macedonia
• Pharmaceutical Manufacturing
• 1 - 100 Employee

• Younger assistant

  • Feb 2006 - Oct 2009

  • Part of the team implementing the quality system based on ISO/IEC 17025:2005 standard in the National Drug Quality Control Laboratory. • Execution of an OMCL Proficiency Testing Study on GC/FID for Drug Quality Control Laboratories• Development of a SPME-GC/MS method for determination of opioid alkaloids in opium (application project, financed by Pharmaceutical Industry Alkaloid, Skopje). • Validation of an ion-pair HPLC-indirect UV detection method for determination of phosphates and phosphites as impurities in sodium risedronate.• Development of a GC/FID method for determination of residual solvents in finished pharmaceutical product (contract research).