Alessandra Breschi

Senior Data Scientist at Verily
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Contact Information
us****@****om
(386) 825-5501
Location
San Francisco Bay Area
Languages
  • English Full professional proficiency
  • Spanish Full professional proficiency
  • French Elementary proficiency
  • Italian Native or bilingual proficiency
  • Catalan Elementary proficiency

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Credentials

  • 18.6501x: Fundamentals of Statistics
    MITx on edX
    Sep, 2020
    - Nov, 2024
  • Deep Learning Specialization
    Coursera
    Jun, 2018
    - Nov, 2024
  • Neural Networks and Deep Learning
    Coursera
    Sep, 2017
    - Nov, 2024
  • Positive Psychology
    Coursera
    Jan, 2016
    - Nov, 2024
  • Machine Learning
    Coursera
    May, 2014
    - Nov, 2024
  • Big Data Analysis with Revolution R Enterprise
    DataCamp
  • Kaggle R Tutorial on Machine Learning
    DataCamp

Experience

    • United States
    • Hospitals and Health Care
    • 700 & Above Employee
    • Senior Data Scientist
      • Mar 2022 - Present

    • United States
    • Biotechnology Research
    • 700 & Above Employee
    • Senior Machine Learning Scientist
      • Feb 2021 - Mar 2022

    • Machine Learning Scientist
      • Jul 2019 - Jan 2021

    • United States
    • Higher Education
    • 700 & Above Employee
    • Postdoctoral Researcher
      • Sep 2017 - Jul 2019

    • Spain
    • Biotechnology Research
    • 200 - 300 Employee
    • Postdoctoral Researcher
      • Dec 2016 - Aug 2017

      Integrative analysis of Next-Generation Sequencing data and personalized genomics (ENCODE consortium).Development of analysis pipelines and visualization tools for RNA-seq, ChIP-seq, DNA-seq in human and other species.

    • Graduate Researcher
      • Dec 2011 - Nov 2016

      Computational Biology of RNA processing Group, Prof. Roderic GuigóDepartment of Bioinformatics and GenomicsMy main scientific interest has been understanding how the DNA is regulated to achieve the transcriptional complexity that we observe between species, and between organs and cell lines within the same species.This question prompted me to be involved in a number of projects:- Analysis of transcription and splicing in human hematopoiesis.As part of the BluePrint consortium, I locally coordinated the data processing and distribution from our group to the rest of the consortium and participated in the study of variation of splicing along hematopoiesis.- Comparative analysis of human and mouse transcriptomes (in collaboration with Dr. Ali Mortazavi, UCI, CA, and Prof. Thomas Gingeras, CSHL, NY).As part of the mouse ENCODE consortium we made major contributions in determining conserved and diverged elements between human and mouse transcriptomes.- Determination of expression variation across multiple species and organs.I propose a new approach to studying expression variation across diverse species.- Exploring the transcriptional determinants of tissue development and commitment in fruitfly.Integrating RNA-seq and ChIP-seq data to understand how multiple tissue evolve during the fruifly development.- Understanding the transcriptional programs at the basis of human cellular diversity (in collaboration with Prof. Thomas Gingeras).As part of the ENCODE consortium I am comparing gene expression and splicing across a broad spectrum of adult human primary cell lines to disentangle the transcriptional complexity of whole organs and building a reference cellular transcriptome to study diseases and altered states in general. Show less

    • United States
    • Higher Education
    • 700 & Above Employee
    • Visiting fellow
      • Sep 2015 - Dec 2015

      In 2015 I was awarded a short-stay fellowship by the Spanish Ministry of Science and Innovation to carry on a scientific collaboration in the team of Dr. Ali Mortazavi, in the Department of Developmental and Cell Biology at UCI (CA). I applied my knowledge of RNA-seq data analysis and comparative transcriptomics to studying genome-wide miRNA expression in a panel of human and mouse embryonic organs, as part of the mouseENCODE and ENCODE projects. I collaborated with the team to optimize a joint miRNA-seq analysis pipeline, investigate the conservation of miRNA sequence and expression between human and mouse, and identify novel miRNA hosts. Show less

    • Spain
    • Research Services
    • 1 - 100 Employee
    • Research Intern
      • Jan 2011 - Jun 2011

      MSc Thesis Internship Structural Bioinformatics Group Task: Network-based prediction of protein phosphorylation Skills: Mining biological databases; network analysis; analysis of protein structures MSc Thesis Internship Structural Bioinformatics Group Task: Network-based prediction of protein phosphorylation Skills: Mining biological databases; network analysis; analysis of protein structures

    • Higher Education
    • 700 & Above Employee
    • Research Intern
      • Apr 2009 - Aug 2009

      BSc Thesis Internship Department of Biochemistry Task: In-vitro screening of PTPB1 inhibitors as potential anti-diabetic drugs. Skills: Molecular cloning; protein purification; enzymatic activity tests; bacterial and mammalian cell culture BSc Thesis Internship Department of Biochemistry Task: In-vitro screening of PTPB1 inhibitors as potential anti-diabetic drugs. Skills: Molecular cloning; protein purification; enzymatic activity tests; bacterial and mammalian cell culture

Education

  • Universitat Pompeu Fabra
    Doctor of Philosophy (PhD), Bioinformatics
    2012 - 2016
  • Universitat Pompeu Fabra
    Master’s Degree, Bioinformatics for Health Sciences
    2009 - 2011
  • Università di Bologna
    MSc, Bioinformatics
    2009 - 2011
  • Università degli Studi di Firenze
    BSc, Biology
    2006 - 2009

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