Experience

Treeway

• Netherlands
• Pharmaceutical Manufacturing
• 1 - 100 Employee

• CMC Translational Scientist

  • Oct 2021 - Present



i3S - Instituto de Investigação e Inovação em Saúde

• Portugal
• Research Services
• 400 - 500 Employee

• PHD Student

  • Mar 2017 - Jul 2021

  Project based on the development of mucoadhesive camptothecin polymeric micelles as nanodelivery systems for oral chemotherapy to treat colorectal cancer.• Planned and organized experiences to meet a strict timeline • Polymer synthesis and characterization• Development of novel polymeric micelles for colorectal cancer treatment• Conducted cell culture, toxicological and permeability tests with several cell lines• Conducted in vivo animal studies (PK, PD and biodistribution)• Drafted and implemented Quality Assurance/Control and Risk Assessment/SOP• Created and maintained database for laboratory materials/equipment inventory• Established International collaborations with technology transfer• Excellent technical writing skills, with several publications and preparation of reportson material-related activities & managing material databases• Disseminated research findings in international conferences/meetings• Supervised master students• Collaboration with +10 PhD students or Postdoctoral researchers• Member of 5 international research projects• Intercultural and international experiences and collaborations (Spain, Israel and Germany);• Participation in several start-up acceleration programsTechniques: Chemical synthesis, polymer characterization, NMR, FTIR, contact angle, TGA, DSC, XRD, GPC, HPLC, DLS, dialysis, fluorescence & confocal microscopy, freeze-drying, cell culture: cell lines and primary cells, cell isolation from blood donors; cell viability and permeability assays; intestinal spheroids, H&E staining, immunohistochemistry, nanosight, spray-drying, 3D printing (FDM and IVF techniques), animal studies (pharmacokinetics, pharmacodynamics and biodistribution), orthotopic and subcutaneous cancer animal models, animal dissection, ChemDraw, AutoCAD, OriginLab, ImageJ, MNova, GraphPad Prism, Microsoft Office Show less

• Research Fellowship (MSc)

  • Jul 2016 - Feb 2017

  Project based on the development of oral strips containing nano encapsulated bioactive compounds.• Solid knowledge in cell culture techniques• Technology transfer• Quality Assurance in lab• Relationships were established and maintained amongst diverse researchers to promote a fruitful and cooperative research environment

• MSc Student

  • Feb 2015 - Jun 2016

  Project based on the development of chitosan-grafed-polycaprolactone copolymer for mucoadhesive nanodelivery systems.• Acquired expertise in a variety of laboratory techniques (carbodiimide chemistry, DLS, polymeric micelles production, in vitro cytotoxicity assays, in vitro intestinal permeability assays)• Organized and presented research results regularly in a laboratory meetings• Presented my work in national and international conferences• Wrote and defended a dissertation



European Space Agency - ESA

• France
• Space Research and Technology
• 700 & Above Employee

• Winner as a team of the Spin Your Thesis program

  • Dec 2019 - Sep 2020

  • Influence of hypergravity on the intestinal permeability of molecules • Built a strong team mentality • Planned and organized the experiments • Managed project logistics • Delivered a paper published in an international peer-reviewed journal Techniques: Space-related research, in vitro intestinal permeability models, confocal microscopy, HPLC, H&E staining, immunohistochemistry • Influence of hypergravity on the intestinal permeability of molecules • Built a strong team mentality • Planned and organized the experiments • Managed project logistics • Delivered a paper published in an international peer-reviewed journal Techniques: Space-related research, in vitro intestinal permeability models, confocal microscopy, HPLC, H&E staining, immunohistochemistry



MJR PharmJet GmbH

• Germany

• Short Term Scientific Mission

  • Oct 2019 - Nov 2019

  Project based on the scale-up process of chitosan derivatives and drug-loaded chitosan micelles. • GMP manufacturing and drug formulation scale-up of chitosan derivatives • Knowledge on GMP and/or FDA/ICH guidelines • Bioreactor for technology transfer • Familiarized with the industrial environment •Trained with quality control procedures in laboratory environment Techniques: Chemical synthesis, polymer characterization, NMR, FTIR, HPLC, DLS, dialysis, freeze-drying, ChemDraw, OriginLab, MNova, Microsoft Office Show less



Grupo Coral de Gandra - JDC

• Gandra - Paredes

• Responsible

  • Dec 2013 - Sep 2019

  https://www.facebook.com/grupocoralgandra https://www.facebook.com/grupocoralgandra



Universidad de Sevilla

• Spain
• Higher Education
• 700 & Above Employee

• Short Term Scientific Mission

  • Jul 2019 - Aug 2019

  Project based on the 3D printed systems filled with chitosan mucoadhesive micelles for colon-specific drug delivery. • 3D printing systems for oral delivery Techniques: DLS, dialysis, freeze-drying, 3D printing (FDM and IVF techniques) Project based on the 3D printed systems filled with chitosan mucoadhesive micelles for colon-specific drug delivery. • 3D printing systems for oral delivery Techniques: DLS, dialysis, freeze-drying, 3D printing (FDM and IVF techniques)



Vall d’Hebron Institute of Research (VHIR) - Vall d'Hebron Institut de Recerca

• Spain
• Research Services
• 500 - 600 Employee

• Visiting PHD Student

  • Sep 2018 - Jul 2019

  In vitro characterization of nanosystems. • Production and characterization of polymeric micelles • 2D&3D cell culture • Delivered oral presentations in regular meetings and seminars Techniques: DLS, dialysis, fluorescence & confocal microscopy, freeze-drying, cell culture: Caco-2 and HT29 cell lines, ChemDraw, OriginLab, MNova, GraphPad Prism In vitro characterization of nanosystems. • Production and characterization of polymeric micelles • 2D&3D cell culture • Delivered oral presentations in regular meetings and seminars Techniques: DLS, dialysis, fluorescence & confocal microscopy, freeze-drying, cell culture: Caco-2 and HT29 cell lines, ChemDraw, OriginLab, MNova, GraphPad Prism



Technion - Israel Institute of Technology

• Israel
• Higher Education
• 700 & Above Employee

• Short Term Scientific Mission

  • Nov 2018 - Dec 2018

  Project based on the physicochemical characterization of chitosan-based polymeric micelles. • Chitosan modifications into amphiphilic polymers • Production and characterization of polymeric micelles by spray-drying Techniques: Spray-drying, DLS, Nanosight, dialysis, freeze-drying Project based on the physicochemical characterization of chitosan-based polymeric micelles. • Chitosan modifications into amphiphilic polymers • Production and characterization of polymeric micelles by spray-drying Techniques: Spray-drying, DLS, Nanosight, dialysis, freeze-drying



Newcastle University

• United Kingdom
• Higher Education
• 700 & Above Employee

• Summer Internship

  • Jul 2016 - Jul 2016

  Project: Single cell encapsulation with chitosan for biomedical applications. Techniques: 3D printing, cell viability assays (live/dead, MTT, LDH, resazurin), DLS, fluorescence microscopy PARSUK (Portuguese association of researchers and students in the UK) is a network that promotes the integration, collaboration and development of Portuguese students and researchers in the UK, through events, conferences and initiatives. The Xperience initiative was the program where I was one of the winners with the possibility of spending 4 weeks working in a project in UK. Show less



BEST Porto

• Portugal
• Non-profit Organization Management
• 1 - 100 Employee

• Member

  • Jun 2015 - Jul 2016

  BEST, Board of European Students of Technology is a constantly growing non-profit and non-political organisation. BEST strives to help European students of technology to become more internationally minded, by reaching a better understanding of European cultures and developing capacities to work on an international basis. BEST, Board of European Students of Technology is a constantly growing non-profit and non-political organisation. BEST strives to help European students of technology to become more internationally minded, by reaching a better understanding of European cultures and developing capacities to work on an international basis.



Hospital Center of Trás-os-Montes e Alto Douro

• Vila Real

• Summer Internship

  • Aug 2014 - Aug 2014

  Oncology Service: From the diagnosis of the patients to the treatment (chemotherapy and radiotherapy). Oncology Service: From the diagnosis of the patients to the treatment (chemotherapy and radiotherapy).