Deep Shah
Senior Manager - Study Oversight at The Jackson Laboratory- Claim this Profile
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Bio
Experience
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The Jackson Laboratory
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United States
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Biotechnology Research
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700 & Above Employee
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Senior Manager - Study Oversight
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Mar 2023 - Present
Sacramento, California, United States
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Study Director
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Jul 2020 - Feb 2023
Sacramento, California, United States
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Champions Oncology, Inc.
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United States
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Biotechnology
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100 - 200 Employee
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Scientific Project Leader
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Oct 2017 - Jun 2020
Rockville, MD
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Loyola University Chicago
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United States
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Higher Education
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700 & Above Employee
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PhD Candidate, Molecular Pharmacology & Therapeutics, Loyola University Chicago
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Sep 2012 - Sep 2017
Cardinal Bernardin Cancer Center Project Title: "Role of Jagged1 in enrichment of Tumor Initiating Cells (TICs) in HER2+ breast cancer" Mentor: Dr. Clodia Osipo The project aims at understanding the mechanism and developing novel biomarkers to combat drug resistance and tumor recurrence in HER2+ subtype of breast cancer. •Examined the effect of HER2 inhibition on Notch signaling by studying surface expression of proteins using flow cytometry •Optimized assays to detect TICs in HER2+ breast cancer after sorting… Show more Project Title: "Role of Jagged1 in enrichment of Tumor Initiating Cells (TICs) in HER2+ breast cancer" Mentor: Dr. Clodia Osipo The project aims at understanding the mechanism and developing novel biomarkers to combat drug resistance and tumor recurrence in HER2+ subtype of breast cancer. •Examined the effect of HER2 inhibition on Notch signaling by studying surface expression of proteins using flow cytometry •Optimized assays to detect TICs in HER2+ breast cancer after sorting the surface marker enriched cancer cells •Performed cell proliferation assay to measure drug resistance •Assessed protein trafficking using flow cytometry and confocal microscopy to discover novel biomarkers for predicting drug resistance and tumor recurrence •Carried out in-vivo studies to determine the therapeutic efficacy of targeting the identified proteins
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Tech Transfer Intern
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May 2016 - May 2017
• Reviewed and presented invention disclosures submitted by Loyola inventors during monthly meetings. • Performed market research to understand the competitive landscape. • Evaluated the commercial potential and market opportunities of each invention. • Participated in business calls and meetings resulting from marketing efforts. Course – Business Foundations Specialization (Coursera Verified)
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Regeneron
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United States
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Biotechnology
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700 & Above Employee
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Commercial Management Intern
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Jun 2017 - Aug 2017
Greater New York City Area
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Laboratory Intern
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Jan 2012 - Apr 2012
Cambridge, MA Coordinated with senior scientists to develop drugs for the treatment of Inflammatory Bowel Disease (IBD).
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Northeastern University
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United States
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Higher Education
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700 & Above Employee
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Graduate Research Assistant
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May 2011 - Dec 2011
"Alginate Polymer Based Particle Trafficking Studies in Macrophage Cell Line" under Dr. Mansoor Amiji. Performed Labeling & Characterization of Alginate polymer with fluorescent dye. Evaluated the uptake of nanoparticles in J774A.1 Macrophage cell line using confocal microscopy.
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Graduate Research Assistant
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Jan 2011 - Jun 2011
New England Inflammation and Tissue Protection Institute Cultured and maintained cancer cell line and performed cell culturing under aseptic conditions. Performed injections (i.d., i.p., i.v., s.c.) and also sub-mandibular and Retro-orbital blood collection Assisted in performing ceacum ligation puncture (CLP) in mice and carried out bacterial plating of blood extracted from sepsis induced mice. Carried out ELISA assay to determine the change in the levels of important mediators and components involved in the immune function Performed… Show more Cultured and maintained cancer cell line and performed cell culturing under aseptic conditions. Performed injections (i.d., i.p., i.v., s.c.) and also sub-mandibular and Retro-orbital blood collection Assisted in performing ceacum ligation puncture (CLP) in mice and carried out bacterial plating of blood extracted from sepsis induced mice. Carried out ELISA assay to determine the change in the levels of important mediators and components involved in the immune function Performed western blot for the detection of phosphorylated STAT-3 protein. Analyzed the genotypes- extracted the DNA obtained from mice tail, carried out PCR to amplify the sequence for CRE gene and performed gel electrophoresis to determine presence of CRE gene
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Graduate Research Assistant
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Dec 2010 - Feb 2011
Pharmaceutical Sciences Department Effectively handled rats and mice and performed in vivo assays for the diuretic, analgesic and temperature studies.
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Education
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Loyola University Chicago
Doctor of Philosophy (PhD), Molecular Pharmacology & Therapeutics -
Northeastern University
Master of Science, Pharmaceutical Sciences -
Ganpat University
Bachelor of Science, Pharmacy