Michelle Percharde
Group Leader (Chromatin and Development Group), UKRI Future Leaders Fellow at MRC London Institute of Medical Sciences- Claim this Profile
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Bio
Experience
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MRC Laboratory of Medical Sciences
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Research Services
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1 - 100 Employee
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Group Leader (Chromatin and Development Group), UKRI Future Leaders Fellow
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Mar 2019 - Present
London, United Kingdom
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University of California, San Francisco
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United States
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Higher Education
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700 & Above Employee
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Postdoctoral Research Scholar
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Mar 2013 - Aug 2018
UCSF Stem Cell Center, San Francisco Investigation into the transcriptional, post-transcriptional and epigenetic regulation of transposable elements in mammalian embryonic stem cells and primordial germ cells. Dissection of genetic and epigenetic reprogramming events in early development. Investigation into the phenomenon of hypertranscription in stem cells and germ cells. Expertise in a wide range of current genome-wide, screen-based and in vivo techniques. Funded by a CIRM Postdoctoral Fellowship (TG2-01153). Techniques:… Show more Investigation into the transcriptional, post-transcriptional and epigenetic regulation of transposable elements in mammalian embryonic stem cells and primordial germ cells. Dissection of genetic and epigenetic reprogramming events in early development. Investigation into the phenomenon of hypertranscription in stem cells and germ cells. Expertise in a wide range of current genome-wide, screen-based and in vivo techniques. Funded by a CIRM Postdoctoral Fellowship (TG2-01153). Techniques: mouse ES cell culture, embryonic dissection and germ cell (PGC) derivation, FACS, genome-wide RNAi, RNA-FISH. Proficient at performing RNA/ChIP/ChIRP-seq and carrying out subsequent downstream bioinformatic analysis (Bash/shell scripting, R, AWS cloud computing) Show less
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San Francisco State University
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United States
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Higher Education
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700 & Above Employee
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Lecturer
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Aug 2016 - Dec 2016
San Francisco Bay Area Lecturer SFSU Fall 2016, BIOL 861: Stem Cell Biology
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Imperial College London
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Research Services
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700 & Above Employee
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PhD Research Student
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Oct 2008 - Feb 2013
Epigenetics and development / molecular endocrinology: PhD 2008-2012: Investigation into the role of nuclear receptor coreguators in controlling embryonic stem cell (ESC) fate and self-renewal, and in the induction of pluripotency in somatic cells via reprogramming and iPS cell generation. Key discovery of Ncoa3 as a novel and essential molecule in ESC self-renewal, and as an obligate coactivator of nuclear receptor Esrrb. Techniques: reprogramming / iPS cell generation, mouse… Show more Epigenetics and development / molecular endocrinology: PhD 2008-2012: Investigation into the role of nuclear receptor coreguators in controlling embryonic stem cell (ESC) fate and self-renewal, and in the induction of pluripotency in somatic cells via reprogramming and iPS cell generation. Key discovery of Ncoa3 as a novel and essential molecule in ESC self-renewal, and as an obligate coactivator of nuclear receptor Esrrb. Techniques: reprogramming / iPS cell generation, mouse ES cell culture, ChIP, ES cell manipulation/ gene function assays, immunofluorescence, qPCR, luciferase assays. Show less
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The Institute of Cancer Research
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United Kingdom
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Research
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700 & Above Employee
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Research Assistant
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Oct 2007 - Jul 2008
London, United Kingdom Identification of novel regulators of tumourigenesis and endocrine resistance in breast cancer cells. Techniques: high-throughput siRNA screening, methylation specific PCR, bisulfite sequencing, tissue culture of cancer cell lines
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Education
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Imperial College London
Doctor of Philosophy (PhD), Epigenetics & Development / Molecular Endocrinology -
University of Cambridge
MA (Cantab) -
University of Cambridge
BA (Hons) Class I, Biochemistry -
Royal Masonic School for Girls