Mizar Therapeutics is a platform therapeutics company using proprietary live-cell, single-molecule imaging and machine-learning technology for discovery of a new class of targeted cancer therapies. Our platform consists of two intertwined elements: live-cell super-resolution imaging and AI-powered data extraction. Our goal: to identify effective condensate modulators to novel targeted cancer therapeutics. Condensates compartmentalizing proteins and nucleic acids are often the location of dysregulation in cancer, and the pharmacodynamics of cancer therapeutics can be affected by condensates. We deploy our live-cell super-resolution technology to determine the interaction of lead compounds and condensate components in intact cells. Our imaging at high frequency and over extended durations gives us unparalleled input data for our machine learning algorithms, meaning novel insight into hit discovery, hit-to-lead, target identification, mode of action and lead optimization.
