Experience

ExcellGene SA

• Switzerland
• Biotechnology Research
• 1 - 100 Employee

• Head Of Analytics

  • Jul 2020 - Present

  • Responsible for leading and ensuring the general performance of the Analytics Dept. (15-20 employees), the cooperation and alignment with other internal/external functions, the support to clients, operations and R&D. • Prioritization of the activities, anticipation of the needs, investigation and implementation of new technologies, improvement of the procedures, the equipment and its preventive/continuous maintenance to ensure the economical and operational efficiency within the designated budget and timelines. • ISO 9001:2015 accreditation, including QMS implementation, method and instrument qualification and digitalization of the reporting procedures in support to data integrity and the establishment of GMP QC platform. Show less



Philip Morris International

• Switzerland
• Tobacco Manufacturing
• 700 & Above Employee

• Researcher

  • Jan 2018 - Dec 2018

  • GLP/FDA lab accreditation (Biomarker & Biosensor Research): preparative and QC/QA process automation including LIMS implementation and data integrity; deviations/non-conformities and CAPA management; instrument maintenance planning and qualification; writing of SOP and WKI. • Genomics platform (clinical trials, microbiomics, de novo genome assembly, etc.): method portfolio development, improvement and validation for both short- (Illumina, IonTorrent, etc.) and long-read/SMRT (PacBio, Oxford Nanopore) sequencing; problem-solving and method/process troubleshooting; post-run data analyses. • Project management for the establishment and routine implementation of a 3rd generation sequencing platform, the investigation and presentation of technical alternatives, designs and/or design improvements. Application of scientific principles to analyze and resolve technical problems and lab management. Show less



ERA-CAPS EU/SNF Joint Research Consortium

• Senior Scientist

  • Nov 2015 - Sep 2017

  • Responsible for the Swiss segment of the SourSi project aimed at multi-locus genome bioengineering. • QbD project and resources management in a trans-disciplinary environment: high-throughput phenotyping, genotyping and metabolic profiling, dissection of complex physiological traits associated with enhanced nutrient allocation for human/animal diet and industrial food processing. • Experimental trial design, execution and management, including scale-up optimization and implementation from laboratory to greenhouse conditions. Show less



Université de Genève

• Switzerland
• Higher Education
• 1 - 100 Employee

• Research scientist

  • May 2013 - Oct 2015

  • Design of biofortification strategies in model/crop species (rice, cassava, tomato, etc.) for improved yield, harvest rate and animal nutrition, with particular reference to Polyamines and Vitamin B1. • Method development, validation and transfer: - improvement of (non-)aqueous fractionation and chemical extraction out of complex and lyophilized/freeze-dried biological matrices - HCS kinetic molecular/enzymatic/immunologic assays and Multi-/Hyperspectral Kinetic Fluorescence Imaging, including scale-up implementation for automated platforms (Applied Biosystems, BMG, BioTek, PSI, Walz, etc.) - metabolomics profiling by (U)HPLC/GC hyphenated to MS, MS/MS and FL/UV/Vis, etc. - hydroponics/soil-free culture and high-throughput micrografting. • Investigation of the effects on the carbohydrate profile, fitness, transcriptome and circadian development of both the long-distance fluxes and the sub-cellular compartmentation of essential metabolites and growth modulators, as well as the involved transporters and molecular receptors. Show less



SystemsX (The Swiss Initiative in Systems Biology)

• Associate Scientist

  • May 2008 - Apr 2013

  • Establishment of an internationally-recognized chemical analytical platform: - fund raising - development and validation of high-throughput UHPLC-MS methods for lipidomics and redox state rapid profiling in different biological matrices. - data analysis and large-scale dataset statistics, data and metadata management. • Extensive laboratory work experience, including (but not limited to): - USP/DSP: molecular cloning, protein synthesis, purification (including automation on GE ÄKTA platforms), and functional/biophysical characterization (2D-SDS-PAGE, Western Blot, ELISA, phospho-proteomics, etc.) of kinases and structural proteins involved in the regulation of high-energy processes. - Design, execution and validation of in vitro enzymatic/immunological/radiological assays. - Protein sub-cellular localization in laser confocal microscopy - Investigation of cell ultrastructural changes by electron microscopy (TEM, SEM) - Determination of the changes in carbohydrate (starch and sugars), pigments and secondary metabolites, etc. • Establishment of a network of factors and feedback mechanisms governing photosynthetic capacity, biomass and genetic/metabolic response during cell/organism acclimation to changing conditions. Show less



Consiglio Nazionale delle Ricerche

• Italy
• Research Services
• 700 & Above Employee

• Research Assistant

  • Oct 2005 - Sep 2007

  • DNA barcoding within the framework of the identification and prevention of food frauds: - Identification of species-specific molecular markers for the study of truffle genetic diversity. - Implementation of the use of gSSH (genomic Suppressive Subtractive Hybridization) as a molecular tool to track microbial species and their products, to identify functional genes and to investigate the genome plasticity, adaptation and evolution. • Design of a novel labelling procedure for the in vivo tracking of heavy metals in both microbial systems and higher organisms and validation against conventional chemical/isotopic analytical methods: - Method development for the in vivo tracking in confocal microscopy of heavy metal species - Precise elemental quantification out of different biological matrices by ICP-AAS (Inductively Coupled Plasma-Atomic Emission Spectrometry). - Use of LCM (Laser Capture Microdissection) for tissue/cell isolation and sample enrichment. • Identification of the molecular mechanisms involved in metal homeostasis in symbiotic associations and their possible application in strategies for enhanced food biosafety and soil phytoremediation. Show less