Experience

Dewpoint Therapeutics

• United States
• Biotechnology Research
• 100 - 200 Employee

• Associate Principal Scientist

  • Sep 2022 - Present

  Boston, Massachusetts, United States

• Senior Scientist - Dewpoint Therapeutics

  • Sep 2021 - Oct 2022

  Boston, Massachusetts, United States



St. Jude Children's Research Hospital

• United States
• Hospitals and Health Care
• 700 & Above Employee

• Postdoctoral Fellow

  • Apr 2012 - Oct 2021

  Characterize physical and biochemical interactions of the yeast protein Ash1 with its cognate ubiquitin ligase. • Develop techniques to prepare high quality samples from truncated regions of Ash1 protein and its binding partners using an array of protein biochemistry and molecular biology techniques. • Used unique combinations of multidimensional NMR, including 2 and 3 dimensional carbon detected experiments, analysis to assign all Ash1 backbone signals in spite of severe signal… Show more Characterize physical and biochemical interactions of the yeast protein Ash1 with its cognate ubiquitin ligase. • Develop techniques to prepare high quality samples from truncated regions of Ash1 protein and its binding partners using an array of protein biochemistry and molecular biology techniques. • Used unique combinations of multidimensional NMR, including 2 and 3 dimensional carbon detected experiments, analysis to assign all Ash1 backbone signals in spite of severe signal overlap. Using these assignments, mapped the specific, atomic level, interactions between Ash1 and the WD40 domain of the SCFCdc4 ubiquitin ligase. • Applied BLI to determine thermodynamics of Ash1 binding. • Developed all atom molecular dynamics simulations of Ash1 and quantified the shortcomings of current MD methods when simulating systems including disordered proteins. • Developed methods and analyzed Ash 1 using Small Angle X-Ray Scattering and analyzed the data using ensemble-based models. Show less



University of Illinois

• United States
• Non-profit Organizations
• 1 - 100 Employee

• Graduate Student

  • 2002 - 2010

• Graduate Student

  • 2002 - 2010